Umc Utrecht

This study is testing whether cannabidiol (CBD) oil can reduce seizures in children aged 1 to 18 with severe epilepsy that doesn't respond to standard treatments. Each child will receive both CBD and a placebo in alternating periods, and their seizures will be tracked using a sma…

This trial tests a fully implantable brain-computer interface (BCI) in one person with a severe spinal cord injury (C1-C4). The device reads brain signals to control digital devices like computers or tablets. Researchers will visit the participant at home 1-3 times per week for a…

This phase 2 trial is testing whether filgotinib, a drug already used for arthritis, can help people with three rare immune diseases: Behçet's disease, myositis, and IgG4-related disease. The goal is to see if it can control disease activity and reduce the need for long-term ster…

This study tests whether adding targeted radiation therapy (SBRT) to standard care helps people with pancreatic cancer that has returned only in the original area live longer and feel better. About 174 adults whose cancer came back locally after surgery will be randomly assigned …

This study tests a precise type of radiation therapy (MRgRT) that aims to protect the nerves and blood vessels needed for erections in 70 men with low- or intermediate-risk prostate cancer. Participants receive 5 high-dose radiation sessions guided by MRI. The goal is to see if t…

This phase 2 trial tests whether etidronate, a drug used for bone disorders, can reduce calcium deposits in the brain and slow disease progression in Fahr's disease or syndrome. 98 adults will receive either etidronate or a placebo for 12 months. The study measures changes in thi…

This early-stage trial tests whether combining high-intensity focused ultrasound (HIFU) with immune checkpoint inhibitors (ipilimumab and nivolumab) is safe and feasible for people with metastatic or unresectable cancer that has worsened after standard treatments. 24 adults will …

This early-phase study tests a new approach for people with a type of esophageal cancer. Participants receive standard chemotherapy followed by a special MRI-guided radiation treatment. The main goal is to find the safest radiation dose and see if this combination can better cont…

This early-phase trial tests whether giving an extra, higher dose of radiation guided by MRI can improve outcomes for people with a type of esophageal cancer. About 30 participants will receive standard chemoradiotherapy plus two extra radiation boosts. The main goal is to find t…

This study follows 40 adults with moderate-to-severe prurigo nodularis who are starting dupilumab (Dupixent). Researchers will track how well the drug controls itching and skin lesions over time, and also study changes in immune cells and proteins in the skin and blood. The goal …

This study tests a brain implant that records brain signals to help people with locked-in syndrome control a computer. Two participants will have 128 electrodes placed on their brain surface. Researchers will train them to use the system at home for one year, aiming for accurate …

This early-phase trial tests whether injecting stem cells (mesenchymal stromal cells) into the hand and forearm muscles can safely help heal painful finger ulcers in people with scleroderma. The study includes 20 participants whose ulcers have not improved with standard treatment…

This study tests a new type of PET/CT scan that uses a radioactive tracer called FAPI to detect an aggressive form of colorectal cancer known as CMS4. The CMS4 subtype is linked to worse outcomes and may not respond well to standard chemotherapy. Researchers will scan 45 patients…

This study tests whether artificial intelligence and special ECG monitoring can improve diagnosis of angina in people whose arteries are not blocked. Researchers will use a Holter monitor at home and an internal ECG during a procedure to detect subtle signs of heart muscle strain…

This study tests whether a 12-week personalized exercise program, done at home with a trainer guiding via video, can improve quality of life and reduce common side effects like fatigue, anxiety, and nerve pain in cancer survivors. About 350 adults who finished cancer treatment wi…

This study tests whether having spine surgery and radiation on the same day helps people with painful spinal tumors recover physical function faster than the usual approach of surgery followed by radiation weeks later. About 100 adults with unstable spinal metastases will be rand…

This study looks at whether a 4-month yoga program can reduce joint pain and stiffness in women with breast cancer who are on hormone therapy. About 140 women who have joint pain from their treatment will either take yoga classes twice a week plus home practice, or join a waiting…

This study tests whether filling the bone gap with a synthetic putty (AttraX Putty) during knee realignment surgery can reduce pain in the first week after surgery. About 40 adults with knee osteoarthritis will be randomly assigned to get the putty or standard surgery without a g…

This study tests whether giving progesterone (a hormone) after intrauterine insemination (IUI) with mild ovarian stimulation increases the chance of a live birth. About 1,000 couples with unexplained infertility will take part. The goal is to see if this simple support can improv…

This study looks at whether a blood test that detects tiny bits of tumor DNA after surgery can help decide which stage II colon cancer patients should get chemotherapy. About 1,320 patients will be randomly assigned to either have their test results used to guide treatment or to …

This study will follow 2500 cancer patients with bone metastases to better understand why some respond to radiation therapy and others do not. Researchers will collect data to build tools that predict pain relief and survival, and to create a platform for testing new treatments. …

This study is a registry that collects detailed information from 1000 adults who have had a spontaneous subarachnoid hemorrhage, a type of stroke. Researchers will analyze treatments and outcomes to find what works best. No new treatments are being tested; the goal is to learn fr…

This study is a large registry that will follow about 8,000 cancer patients who receive radiation therapy using a special machine called an MR-Linac, which combines an MRI scanner with a radiation beam. The goal is to learn how well this technology works for different cancers, in…

This study is creating a large registry of 1,500 men with newly diagnosed prostate cancer. Researchers will track their health, side effects, and quality of life over time to better understand how different treatments affect patients. The goal is to build a platform for future st…

This study follows 600 people with hip or knee osteoarthritis for one year to understand how their symptoms and daily function change over time. Participants fill out online questionnaires every two weeks and try different self-care programs through a web app called ArtroseCoach.…

This study tests an online clinic (eCG Family Clinic) that helps families with inherited heart conditions get genetic counseling and DNA testing from home. Researchers will see if more family members use the service and how satisfied they are compared to standard care. About 170 …