Blood test may spare some colon cancer patients from chemo

NCT ID NCT06434896

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether a blood test that detects tiny bits of tumor DNA after surgery can help decide which stage II colon cancer patients should get chemotherapy. About 1,320 patients will be randomly assigned to either have their test results used to guide treatment or to receive standard care. The goal is to see if more patients with a positive test start chemo, and whether this approach reduces cancer recurrence.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

ctDNA blood test

What this could lead to

If successful, this could show that a simple blood test can identify which stage II colon cancer patients need chemotherapy after surgery, avoiding unnecessary treatment for others.

What could go wrong

This is an early-stage observational study, not a treatment trial. The test may not accurately predict recurrence, and the results may not change standard care.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

colon carcinoma colonic neoplasm malignant colon neoplasm Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Admiraal de Ruyter Ziekenhuis

    RECRUITING

    Goes, Netherlands

    Contact

  • Albert Schweizer Ziekenhuis

    RECRUITING

    Dordrecht, Netherlands

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  • Amphia Ziekenhuis

    RECRUITING

    Breda, Netherlands

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  • Bernhoven

    RECRUITING

    Uden, Netherlands

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  • Bravis Ziekenhuis

    RECRUITING

    Roosendaal, Netherlands

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  • Canisius Wilhelmina Ziekenhuis

    RECRUITING

    Nijmegen, Netherlands

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  • Deventer Ziekenhuis

    RECRUITING

    Deventer, Netherlands

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  • Diakonessenhuis

    RECRUITING

    Utrecht, Netherlands

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  • Flevoziekenhuis

    RECRUITING

    Almere Stad, Netherlands

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  • Haaglanden MC

    RECRUITING

    The Hague, Netherlands

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  • Ikazia Ziekenhuis

    RECRUITING

    Rotterdam, Netherlands

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  • Jeroen Bosch Ziekenhuis

    RECRUITING

    's-Hertogenbosch, Netherlands

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  • Maastricht UMC

    RECRUITING

    Maastricht, Netherlands

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  • Maxima Medisch Centrum

    RECRUITING

    Veldhoven, Netherlands

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  • Meander Medisch Centrum

    RECRUITING

    Amersfoort, Netherlands

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  • NKI-AVL

    RECRUITING

    Amsterdam, Netherlands

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  • Noordwest Ziekenhuisgroep

    RECRUITING

    Alkmaar, Netherlands

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  • Reinier de Graaf Gasthuis

    RECRUITING

    Delft, Netherlands

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  • Rijnstate

    RECRUITING

    Arnhem, Netherlands

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  • Rivas

    RECRUITING

    Gorinchem, Netherlands

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  • Spaarne Gasthuis

    RECRUITING

    Haarlem, Netherlands

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  • St. Antonius Ziekenhuis

    RECRUITING

    Nieuwegein, Netherlands

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  • St. Jans Gasthuis

    RECRUITING

    Weert, Netherlands

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  • UMC Utrecht

    RECRUITING

    Utrecht, Netherlands

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  • Van Weel-Bethesda Ziekenhuis

    RECRUITING

    Middelharnis, Netherlands

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  • VieCuri Medisch Centrum

    RECRUITING

    Venlo, Netherlands

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  • Ziekenhuis Gelderse Vallei

    RECRUITING

    Ede, Netherlands

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  • Ziekenhuis St. Jansdal

    RECRUITING

    Harderwijk, Netherlands

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  • Ziekenhuisgroep Twente

    RECRUITING

    Almelo, Netherlands

    Contact