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DNA clues may reveal which esophageal cancers will return soon after surgery

NCT ID NCT06476067

Recruiting now Knowledge-focused Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This study looks at whether changes in DNA methylation—a type of epigenetic marker—can help predict if esophageal cancer will come back soon after surgery. Researchers will analyze tumor tissue from 150 patients who had their cancer removed and track who experiences a recurrence within two years. The goal is to develop a biomarker that flags high-risk patients earlier, potentially guiding closer monitoring or additional treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could lead to a blood or tissue test that helps doctors identify patients at high risk of early cancer return after surgery.
What could go wrong
This is an observational study, not a treatment trial. The findings may not translate into a reliable clinical test, and the sample size is modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

esophageal cancer Esophageal Neoplasms esophageal squamous cell carcinoma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DNA METHYLATION ESOPHAGEAL CANCER RECURRENCE

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Nagoya University

    RECRUITING

    Nagoya, Aichi-ken, 4668560, Japan

    Contact Email: •••••@•••••

  • Yamanashi Universiy

    RECRUITING

    Chūō, Yamanashi, 4093898, Japan

    Contact Email: •••••@•••••

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