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Can custom vitamin pills fix nutrient gaps after stomach or esophageal cancer surgery?

NCT ID NCT05281380

Disease control Sponsor: Zuyderland Medisch Centrum Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 04, 2026 · Last updated Sep 04, 2026

Summary

This study tests whether tailored vitamin and mineral supplements can correct nutrient deficiencies that often follow surgery for esophageal or gastric cancer. Researchers will enroll 107 adults who had either an esophagectomy or a (sub-)total gastrectomy for cancer and show no signs of recurrence. Participants receive one of two custom supplements based on their surgery type, and researchers measure micronutrient levels and quality of life at baseline and after 6, 12, and 24 months. The goal is to see if routine supplementation can improve nutritional status and daily well-being after these major operations.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Tailor-made vitamin and mineral supplements, one for patients who had esophagectomy and one for those who had (sub-)total gastrectomy
What this could lead to
If it works, this could point toward a standard way to detect and treat vitamin deficiencies after esophageal or gastric cancer surgery, improving recovery and quality of life.
What could go wrong
This is a single-center study with no control group, so results may not apply broadly. Supplements may not fully correct all deficiencies, and benefits for quality of life remain uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

107 people

The number who actually took part.

Started

Dec 2021

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: A potential subject who meets any of the following criteria will be included for participation in this study: * Patients ≥18 years of age who underwent an esophagectomy or (sub)total gastrectomy for malignancy with no signs of postoperative recurrence of disease. * Written voluntary informed consent (IC). Exclusion Criteria: \- A potential subject who meets any of the following criteria will be excluded from participation in this study: * Patients that underwent a wedge resection of the stomach * Malignant disease recurrence * Metastases * Patients that are not capable to take supplementation due to altered mental status or swallow difficulties * No signed informed consent * Patients who are receiving chemotherapy * Patients with high vitamin status at baseline

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Conditions

The condition(s) this trial relates to.

esophageal cancer Esophageal Neoplasms gastric cancer gastric neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Esophageal cancer Gastric cancer Quality of life Vitamin disease

Contacts and locations

Locations

  • ZuyderlandMC

    Sittard, Limburg, 6130MB, Netherlands

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