CBD oil put to the test for kids with Hard-to-Control seizures

NCT ID NCT07668856

Recruiting now Disease control Sponsor: UMC Utrecht Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether cannabidiol (CBD) oil can reduce seizures in children aged 1 to 18 with severe epilepsy that doesn't respond to standard treatments. Each child will receive both CBD and a placebo in alternating periods, and their seizures will be tracked using a smartphone app. The goal is to see if CBD works better than placebo for each individual child, while also monitoring safety and side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Cannabidiol (CBD) oral solution
What this could lead to: If it works, this could provide a personalized treatment option for children with hard-to-control epilepsy, reducing seizure frequency and improving quality of life.
What could go wrong: This is a small Phase 3 trial with only 50 participants, and results may not apply to all children. CBD may cause side effects like drowsiness or liver issues, and the benefit over placebo may be modest or absent for some.

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Conditions

The condition(s) this trial relates to.

Drug Resistant Epilepsy epilepsy Rare Diseases

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EPILEPSY REFRACTORY EPILEPSY REFRACTORY EPILEPSY IN CHILDREN

Contacts and locations

Locations

University Medical Center Utrecht
RECRUITING

Utrecht, Utrecht, 3584 CX, Netherlands

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