Can invisible electric fields quiet the Brain's seizure signals?

NCT ID NCT06716866

ENROLLING_BY_INVITATION Disease control Sponsor: University of California, Davis Source: ClinicalTrials.gov ↗

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This trial tests whether a non-invasive technique called temporally-interfering electric field stimulation (TIEFS) can reduce abnormal brain activity linked to epilepsy. Researchers will measure seizure-related signals in patients with medial temporal lobe epilepsy who are already undergoing brain monitoring. The study compares these signals during no stimulation, sham stimulation, and active TIEFS to see if the device can dampen them.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: temporally-interfering electric field stimulation (TIEFS), a non-invasive device that uses electric fields to modulate brain activity
What this could lead to: If effective, this could offer a non-invasive, drug-free way to reduce seizure-related brain activity, potentially leading to a new treatment for epilepsy.
What could go wrong: This is an early, exploratory study focused on brain signals, not seizure outcomes. The effect may not translate to real-world seizure reduction, and the device's safety and efficacy are not yet established.

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Conditions

The condition(s) this trial relates to.

epilepsy temporal lobe epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EPILEPSY

Contacts and locations

Locations

Emory University Hospital

Atlanta, Georgia, 30322, United States
St. Anne Hospital, Masaryk University

Brno, Czechia
UC Davis Medical Center

Sacramento, California, 95817, United States

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