Temporal lobe epilepsy

This study tests brain surgery as a treatment for people whose epilepsy doesn't improve with medication. About 300 children and adults aged 8 and older will have surgery to remove or treat the part of the brain causing seizures. The goal is to stop or greatly reduce seizures, tho…

This Phase 3 trial tests a single inhaled dose of alprazolam (a fast-acting sedative) to stop prolonged seizures in people aged 12 and older. The goal is to see if it can end a seizure within 90 seconds and prevent it from coming back for at least 2 hours. About 350 participants …

This study tests a one-time injection of lab-grown nerve cells (NRTX-1001) into the brain for people with a specific type of epilepsy that doesn't respond to medication. The cells are designed to release a calming chemical called GABA to quiet overactive brain signals. Researcher…

This early-stage study tests a new gene therapy called AMT-260 in 12 adults with a severe form of epilepsy that doesn't respond to standard medications. The treatment is delivered directly into the brain using MRI guidance. The main goals are to check safety and see if it can red…

This study tests a personalized deep brain stimulation (DBS) method for people with epilepsy that starts in the memory center of the brain. Eight participants will receive a device that sends low-frequency electrical pulses to specific brain networks, with the goal of reducing se…

This pilot study tests a device called NaviFUS that uses low-intensity focused ultrasound to calm overactive brain areas. It involves 16 adults with drug-resistant epilepsy who still have frequent seizures despite trying at least three medications. The goal is to see if the treat…

This study tests a minimally invasive laser treatment for people with drug-resistant temporal lobe epilepsy. The procedure uses heat from a laser to destroy the small part of the brain causing seizures. Researchers will track whether patients become seizure-free and how their mem…

This early-stage trial tests a one-time injection of special nerve cells (NRTX-1001) into both sides of the brain in 10 adults with drug-resistant epilepsy. The cells are designed to calm overactive brain signals by releasing GABA. The main goal is safety, but researchers will al…

This study is testing a small device that fits in the ear to detect seizures by measuring brain waves. Researchers will first test it on 5 healthy people, then on 10 people with epilepsy who are already scheduled for a standard scalp EEG. The goal is to see if the in-ear device i…

This pilot trial tests whether repeated sessions of pulsed low-intensity focused ultrasound can safely reduce seizures in people with drug-resistant temporal lobe epilepsy. Ten adults who still have seizures despite medication will receive the ultrasound treatment. Researchers wi…

This early study tests a device that uses low-intensity focused ultrasound to calm overactive brain areas in people with drug-resistant temporal lobe epilepsy. Eight adults will receive up to three 10-minute ultrasound sessions. Researchers will track side effects and check if se…

This study investigates how rehearsal (repeating information) and sleep help solidify memories in people with epilepsy. Participants learn object-location pairs, with some pairs rehearsed and others not, and their memory is tested after a short delay and again after 12 hours—eith…

This study screens children and adults aged 8 and older with known or suspected epilepsy, especially those whose seizures are not controlled by medication. Participants undergo tests like EEG, MRI, and PET scans to characterize their epilepsy. The goal is to find suitable candida…

This study looks at how epileptic brain activity during sleep can cause awakenings and change dream recall or content. Researchers will use tiny electrical pulses in the brain during sleep to trigger mild epileptic activity and observe the effects. The goal is to better understan…

This study follows 2,300 children with epilepsy to see how their thinking and learning abilities change over many years. Researchers will track brain development, seizure control, and quality of life. The goal is to find early signs that predict how a child's cognitive skills wil…

This study explores how the brain recognizes and remembers places, using virtual tours and brain recordings in people with epilepsy. Researchers aim to map the brain regions critical for spatial memory, so surgeons can avoid them during epilepsy surgery. Over 600 participants, in…

This study tests a special MRI method using ferumoxytol, an iron-based contrast agent, to get clearer images of tiny blood vessels in the brain's memory center (hippocampus) in people with temporal lobe epilepsy. Researchers aim to see if these images can help predict who will be…

This study looks at how a focal seizure (a seizure starting in one part of the brain) temporarily changes a person's ability to pay attention. Researchers will test 100 adults with epilepsy before and after a seizure using attention tasks and brain wave recordings. The goal is to…

This study aims to find genetic mutations in the brain that cause drug-resistant epilepsy in children. Researchers will compare DNA from blood and brain tissue, including samples from special electrodes placed in the brain. The goal is to better understand the root causes of thes…

This study combines advanced MRI scans with intracranial EEG recordings to map brain networks in people with drug-resistant epilepsy. Researchers aim to develop noninvasive imaging biomarkers that predict where seizures start and how they spread. The goal is to improve surgical o…

This study is developing a platform called CAMERA that uses wristband sensors and smartphone data to predict anxiety and memory states in people with epilepsy. Researchers will monitor 40 patients in the hospital to see how brain, body, and behavior signals relate. The goal is to…

This study uses powerful MRI scanners to look at the brains and spinal cords of 700 people, including healthy volunteers and those with conditions like multiple sclerosis, Alzheimer's, and Parkinson's. The goal is to understand why some brains stay healthy while others decline. R…