Gene therapy breakthrough targets severe epilepsy in first human trial

NCT ID NCT06063850

Recruiting now Disease control Sponsor: UniQure Biopharma B.V. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 30, 2026 · Updated 2 times

Summary

This early-stage study tests a new gene therapy called AMT-260 in 12 adults with a severe form of epilepsy that doesn't respond to standard medications. The treatment is delivered directly into the brain using MRI guidance. The main goals are to check safety and see if it can reduce seizure frequency over one year.

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Conditions

The condition(s) this trial relates to.

epilepsy Epileptic Syndromes Hippocampal Sclerosis mesial temporal lobe epilepsy with hippocampal sclerosis temporal lobe epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MESIAL TEMPORAL LOBE EPILEPSY

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Allegheny Health Network
RECRUITING

Pittsburgh, Pennsylvania, 15212, United States
Baylor Scott & White Medical Center
RECRUITING

Austin, Texas, 78735, United States
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Corewell Health
RECRUITING

Grand Rapids, Michigan, 49503, United States
Dartmouth Hitchcock Medical Center
RECRUITING

Lebanon, New Hampshire, 03756, United States
Hospital of the University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Johns Hopkins School of Medicine
RECRUITING

Baltimore, Maryland, 21287, United States
Kansas University Medical Center
RECRUITING

Kansas City, Kansas, 66160, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic Arizona
RECRUITING

Phoenix, Arizona, 85054, United States
Mayo Clinic Florida
RECRUITING

Jacksonville, Florida, 32224, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Midatlantic Epilepsy and Sleep Center
COMPLETED

Bethesda, Maryland, 20817, United States
Northeast Regional Epilepsy Group
RECRUITING

Hackensack, New Jersey, 07601, United States
Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
Robert Wood Johnson Hospital
RECRUITING

New Brunswick, New Jersey, 08901, United States
Stanford University
RECRUITING

Palo Alto, California, 94304, United States
University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35294-0021, United States

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