Brain cell transplant shows promise for Tough-to-Treat epilepsy
NCT ID NCT05135091
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a one-time injection of lab-grown nerve cells (NRTX-1001) into the brain for people with a specific type of epilepsy that doesn't respond to medication. The cells are designed to release a calming chemical called GABA to quiet overactive brain signals. Researchers will compare seizure reduction in 88 participants who receive either the cell therapy or a sham procedure.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
NRTX-1001 (lab-grown nerve cells that release GABA, a calming chemical in the brain)
What this could lead to
If it works, this could offer a new way to control seizures in people with drug-resistant epilepsy, potentially reducing or eliminating the need for daily medication.
What could go wrong
This is still experimental and in early Phase 3 testing. It may not work for everyone, and there are risks from the brain injection procedure. Long-term effects are unknown.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for MESIAL TEMPORAL LOBE EPILEPSY are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Atrium Health
RECRUITINGCharlotte, North Carolina, 28204, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Atrium Wake Forest Baptist
RECRUITINGWinston-Salem, North Carolina, 27157, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Banner-University of Arizona Medical Center Tucson Comprehensive Epilepsy Program
RECRUITINGTucson, Arizona, 85724-5023, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Beth Israel Deaconess Medical Center
RECRUITINGBoston, Massachusetts, 02215, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Dartmouth Hitchcock Medical Center/ Department of Neurology
RECRUITINGLebanon, New Hampshire, 03756, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Duke University Hospital
RECRUITINGDurham, North Carolina, 27710, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
George Washington University
RECRUITINGWashington D.C., District of Columbia, 20037, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Hofstra Northwell Comprehensive Epilepsy Center
RECRUITINGGreat Neck, New York, 11021, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Mayo Clinic Arizona Epilepsy Center
RECRUITINGPhoenix, Arizona, 85054, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Medical College of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
NYU Langone Comprehensive Epilepsy Center
RECRUITINGNew York, New York, 10016, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Ochsner Clinic Foundation
RECRUITINGNew Orleans, Louisiana, 70121, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Oregon Health and Science University
RECRUITINGPortland, Oregon, 97239, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Rush University Medical Center
RECRUITINGChicago, Illinois, 60612, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
SUNY Upstate Medical University
RECRUITINGSyracuse, New York, 13210, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Stanford University
RECRUITINGPalo Alto, California, 94304, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Thomas Jefferson University Hospital
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
UC Irvine Medical Center
RECRUITINGOrange, California, 92868, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
UT Southwestern Medical Center
RECRUITINGDallas, Texas, 75390, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
UTHealth Houston
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
University of Alabama
RECRUITINGBirmingham, Alabama, 35294, United States
Contact Email: •••••@•••••
Contact
-
University of Arkansas for Medical Sciences
RECRUITINGLittle Rock, Arkansas, 72205, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
University of California Davis
RECRUITINGSacramento, California, 95817, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
University of California Los Angeles
RECRUITINGLos Angeles, California, 90095, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
University of California San Diego
RECRUITINGSan Diego, California, 92037, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University of California San Francisco
RECRUITINGSan Francisco, California, 94143, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University of Chicago
RECRUITINGChicago, Illinois, 60637, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
University of Colorado Anschutz Medical Campus
RECRUITINGAurora, Colorado, 80045, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University of Iowa Health Care
RECRUITINGIowa City, Iowa, 52242, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
University of Miami
RECRUITINGMiami, Florida, 33136, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University of Southern California Keck Hospital
RECRUITINGLos Angeles, California, 90033, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University of Utah Health
RECRUITINGSalt Lake City, Utah, 84108, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
University of Washington Regional Epilepsy Center
RECRUITINGSeattle, Washington, 98104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
-
Washington University at St. Louis
RECRUITINGSt Louis, Missouri, 63100, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
-
Wayne State University/Detroit Medical Center Comprehensive Epilepsy Program
RECRUITINGDetroit, Michigan, 48201, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact