Brain cell transplant shows promise for Tough-to-Treat epilepsy

NCT ID NCT05135091

Recruiting now Disease control Sponsor: Neurona Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a one-time injection of lab-grown nerve cells (NRTX-1001) into the brain for people with a specific type of epilepsy that doesn't respond to medication. The cells are designed to release a calming chemical called GABA to quiet overactive brain signals. Researchers will compare seizure reduction in 88 participants who receive either the cell therapy or a sham procedure.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: NRTX-1001 (lab-grown nerve cells that release GABA, a calming chemical in the brain)
What this could lead to: If it works, this could offer a new way to control seizures in people with drug-resistant epilepsy, potentially reducing or eliminating the need for daily medication.
What could go wrong: This is still experimental and in early Phase 3 testing. It may not work for everyone, and there are risks from the brain injection procedure. Long-term effects are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

epilepsy mesial temporal lobe epilepsy with hippocampal sclerosis temporal lobe epilepsy visual epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MESIAL TEMPORAL LOBE EPILEPSY

Contacts and locations

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Locations

Atrium Health
RECRUITING

Charlotte, North Carolina, 28204, United States
Atrium Wake Forest Baptist
RECRUITING

Winston-Salem, North Carolina, 27157, United States
Banner-University of Arizona Medical Center Tucson Comprehensive Epilepsy Program
RECRUITING

Tucson, Arizona, 85724-5023, United States
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
Dartmouth Hitchcock Medical Center/ Department of Neurology
RECRUITING

Lebanon, New Hampshire, 03756, United States
Duke University Hospital
RECRUITING

Durham, North Carolina, 27710, United States
George Washington University
RECRUITING

Washington D.C., District of Columbia, 20037, United States
Hofstra Northwell Comprehensive Epilepsy Center
RECRUITING

Great Neck, New York, 11021, United States
Mayo Clinic Arizona Epilepsy Center
RECRUITING

Phoenix, Arizona, 85054, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
NYU Langone Comprehensive Epilepsy Center
RECRUITING

New York, New York, 10016, United States
Ochsner Clinic Foundation
RECRUITING

New Orleans, Louisiana, 70121, United States
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States
Rush University Medical Center
RECRUITING

Chicago, Illinois, 60612, United States
SUNY Upstate Medical University
RECRUITING

Syracuse, New York, 13210, United States
Stanford University
RECRUITING

Palo Alto, California, 94304, United States
Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
UC Irvine Medical Center
RECRUITING

Orange, California, 92868, United States
UT Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
UTHealth Houston
RECRUITING

Houston, Texas, 77030, United States
University of Alabama
RECRUITING

Birmingham, Alabama, 35294, United States
University of Arkansas for Medical Sciences
RECRUITING

Little Rock, Arkansas, 72205, United States
University of California Davis
RECRUITING

Sacramento, California, 95817, United States
University of California Los Angeles
RECRUITING

Los Angeles, California, 90095, United States
University of California San Diego
RECRUITING

San Diego, California, 92037, United States
University of California San Francisco
RECRUITING

San Francisco, California, 94143, United States
University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States
University of Colorado Anschutz Medical Campus
RECRUITING

Aurora, Colorado, 80045, United States
University of Iowa Health Care
RECRUITING

Iowa City, Iowa, 52242, United States
University of Miami
RECRUITING

Miami, Florida, 33136, United States
University of Southern California Keck Hospital
RECRUITING

Los Angeles, California, 90033, United States
University of Utah Health
RECRUITING

Salt Lake City, Utah, 84108, United States
University of Washington Regional Epilepsy Center
RECRUITING

Seattle, Washington, 98104, United States

Contact Email: •••••@•••••
Washington University at St. Louis
RECRUITING

St Louis, Missouri, 63100, United States
Wayne State University/Detroit Medical Center Comprehensive Epilepsy Program
RECRUITING

Detroit, Michigan, 48201, United States

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