Temporal lobe epilepsy
MONDO:0005115A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe, most commonly from its mesial aspect. A wide variety of psychic phenomena may be associated, including illusions, hallucinations, dyscognitive states, and affective experiences. The majority of complex partial seizures (see epilepsy, complex partial) originate from the temporal lobes. Temporal lobe seizures may be classified by etiology as cryptogenic, familial, or symptomatic (i.e., related to an identified disease process or lesion). (From Adams et al., Principles of Neurology, 6th ed, p321)
Also known as: epilepsy of temporal lobe, epilepsy, familial temporal lobe, familial temporal lobe epilepsy syndrome, temporal lobe epilepsy
36 clinical trials for this condition and its sub-types.
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Broader categories
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Real-World study tracks Epidyolex's Long-Term impact on seizures
Disease control OngoingThis study follows 158 people in France who are prescribed Epidyolex (a cannabidiol-based medicine) for seizures as part of their normal care. Researchers will track how long people stay on the treatment, side effects, seizure frequency, and changes in daily functioning and quali…
Sponsor: Jazz Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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AI boosts brain scan accuracy in massive new trial
Diagnosis ENROLLING_BY_INVITATIONThis study tests whether an AI tool can help radiologists read brain CT and MRI scans more accurately and quickly. Researchers will compare how well doctors, AI alone, and doctors using AI together can spot abnormalities, urgent findings, and classify diseases. The goal is to red…
Sponsor: Yaou Liu • Aim: Diagnosis
Last updated Jun 27, 2026 11:00 UTC
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Scientists dig into brain genes to unlock epilepsy mysteries
Knowledge-focused OngoingThis study looks at gene activity in brain tissue removed during surgery from 10 people with temporal lobe epilepsy and hippocampal sclerosis. The goal is to find which genes are linked to the disease and may help predict outcomes. No new treatment is being tested; instead, resea…
Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:25 UTC
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Zapping the Brain's memory network: a new hope for epilepsy?
Knowledge-focused ENROLLING_BY_INVITATIONThis pilot study at the University of Chicago is testing whether a non-invasive brain stimulation technique called TMS can improve memory and reduce seizure-related brain activity in people with mesial temporal lobe epilepsy (MTLE). Thirty-four adults with drug-resistant MTLE wil…
Phase: NA • Sponsor: University of Chicago • Aim: Knowledge-focused
Last updated Jun 26, 2026 16:21 UTC
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300 volunteers help create medical image bank for science
Knowledge-focused OngoingThis study gathers MRI, CT, and ultrasound images from 300 adults—some healthy, some with kidney or brain disease—to build a collection for future not-for-profit research. No new treatments are being tested; the goal is to make medical images available to scientists for advancing…
Sponsor: Mario Negri Institute for Pharmacological Research • Aim: Knowledge-focused
Last updated Jun 26, 2026 13:28 UTC