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Temporal lobe epilepsy
MONDO:0005115A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe, most commonly from its mesial aspect. A wide variety of psychic phenomena may be associated, including illusions, hallucinations, dyscognitive states, and affective experiences. The majority of complex partial seizures (see epilepsy, complex partial) originate from the temporal lobes. Temporal lobe seizures may be classified by etiology as cryptogenic, familial, or symptomatic (i.e., related to an identified disease process or lesion). (From Adams et al., Principles of Neurology, 6th ed, p321)
Also known as: epilepsy of temporal lobe, epilepsy, familial temporal lobe, familial temporal lobe epilepsy syndrome, temporal lobe epilepsy
36 clinical trials for this condition and its sub-types.
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New MRI techniques may sharpen seizure surgery targeting
Diagnosis Not yet recruitingThis study tests whether combining standard MRI with two advanced techniques—MRI volumetry and diffusion tensor imaging—can more accurately identify the seizure-causing brain area in people with temporal lobe epilepsy. Researchers will compare these imaging results with clinical …
Sponsor: Assiut University • Aim: Diagnosis
Last updated Jun 27, 2026 09:01 UTC
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Could a night of brain zapping improve sleep and seizures in epilepsy?
Symptom relief Not yet recruitingThis study tests whether a non-invasive brain stimulation technique called temporal interference (TI) can reduce abnormal brain activity and improve sleep in adults with drug-resistant temporal lobe epilepsy. Twenty participants will stay in a sleep lab for six nights, receiving …
Phase: NA • Sponsor: Duke University • Aim: Symptom relief
Last updated Jun 27, 2026 12:32 UTC
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Zapping the brain without surgery: new hope for epilepsy?
Symptom relief Not yet recruitingThis study tests a new, non-invasive brain stimulation method called temporal interference (TI) for people with drug-resistant temporal lobe epilepsy. 30 adults will receive 5 days of TI stimulation targeting the hippocampus. The goal is to see if this reduces seizure frequency o…
Phase: NA • Sponsor: Xijing Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:07 UTC
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New MRI scan could pinpoint epilepsy hotspots without surgery
Knowledge-focused Not yet recruitingThis study explores whether a special MRI technique called CEST can locate the brain area causing seizures in people with drug-resistant epilepsy. Researchers will scan 20 patients before surgery and compare the MRI results with standard methods. If it works, this could reduce th…
Phase: NA • Sponsor: Fondation Ophtalmologique Adolphe de Rothschild • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:09 UTC