Could a night of brain zapping improve sleep and seizures in epilepsy?
NCT ID NCT07434986
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a non-invasive brain stimulation technique called temporal interference (TI) can reduce abnormal brain activity and improve sleep in adults with drug-resistant temporal lobe epilepsy. Twenty participants will stay in a sleep lab for six nights, receiving TI stimulation during sleep on some nights and no stimulation on others. Researchers will compare seizure-related brain activity and sleep quality between these nights to see if the stimulation helps.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Non-invasive temporal interference (TI) electrical stimulation
- What this could lead to
- If it works, this could point toward a non-invasive way to reduce seizure-related brain activity and improve sleep for people with drug-resistant epilepsy.
- What could go wrong
- This is a very small early study with only 20 participants, so results may not apply to everyone. The stimulation may not reduce seizure activity or improve sleep, and side effects are not yet well understood.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Anphy Lab - Inside Hock Plaza
Durham, North Carolina, 27705, United States
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