Sound waves aimed at the brain could tame seizures

NCT ID NCT06388707

Recruiting now Symptom relief Sponsor: NaviFUS Corporation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early study tests a device that uses low-intensity focused ultrasound to calm overactive brain areas in people with drug-resistant temporal lobe epilepsy. Eight adults will receive up to three 10-minute ultrasound sessions. Researchers will track side effects and check if seizure frequency changes. The goal is to see if this non-invasive approach is safe and worth studying further.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: low-intensity focused ultrasound (LIFU) device
What this could lead to: If it works, this could point toward a non-invasive treatment option for people with drug-resistant epilepsy, potentially reducing seizure frequency without surgery.
What could go wrong: This is a very small, early pilot study with only 8 participants, so results may not apply widely. The treatment is still experimental, and safety and effectiveness are not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Drug Resistant Epilepsy epilepsy focal epilepsy temporal lobe epilepsy visual epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DRUG-RESISTANT EPILEPSY EPILEPSY SEIZURE SEIZURE DISORDER SEIZURES, FOCAL

Contacts and locations

Locations

Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
Stanford University School of Medicine
RECRUITING

Palo Alto, California, 94305, United States
University of Virginia School of Medicine
RECRUITING

Charlottesville, Virginia, 22903, United States

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