Can a High-Fat diet and therapy tame seizures in rare childhood epilepsy?
NCT ID NCT07745608
First seen Aug 04, 2026 · Last updated Aug 07, 2026 · Updated 2 times
Summary
This study asks whether adding a medically supervised ketogenic diet to occupational therapy can help children aged 4 to 7 with ARX gene mutations and drug-resistant epilepsy. Twenty children will take part: half follow the ketogenic diet while the other half do not, and both groups receive occupational therapy for 16 weeks. Researchers will track seizure frequency, motor skills, balance, sensory processing, chewing, eating behaviors, and quality of life to see if the diet makes a meaningful difference.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Medical ketogenic diet therapy combined with individualized occupational therapy
- What this could lead to
- If effective, this combination could offer a non-drug way to reduce seizures and improve motor and daily living skills in children with ARX-related epilepsy.
- What could go wrong
- The trial is small (20 children) and early, so results may not apply broadly. The ketogenic diet can be hard to follow and may have side effects.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Ilk Evre Special Education and Rehabilitation Center
Istanbul, Istanbul, 34418, Turkey (Türkiye)
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