Can a High-Fat diet and therapy tame seizures in rare childhood epilepsy?

NCT ID NCT07745608

First seen Aug 04, 2026 · Last updated Aug 07, 2026 · Updated 2 times

Summary

This study asks whether adding a medically supervised ketogenic diet to occupational therapy can help children aged 4 to 7 with ARX gene mutations and drug-resistant epilepsy. Twenty children will take part: half follow the ketogenic diet while the other half do not, and both groups receive occupational therapy for 16 weeks. Researchers will track seizure frequency, motor skills, balance, sensory processing, chewing, eating behaviors, and quality of life to see if the diet makes a meaningful difference.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Medical ketogenic diet therapy combined with individualized occupational therapy
What this could lead to
If effective, this combination could offer a non-drug way to reduce seizures and improve motor and daily living skills in children with ARX-related epilepsy.
What could go wrong
The trial is small (20 children) and early, so results may not apply broadly. The ketogenic diet can be hard to follow and may have side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ARX GENE MUTATION are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

developmental and epileptic encephalopathy, 1 Drug Resistant Epilepsy Feeding Behavior

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Ilk Evre Special Education and Rehabilitation Center

    Istanbul, Istanbul, 34418, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.