Brain cell injection could tame epilepsy seizures
NCT ID NCT06422923
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial tests a one-time injection of special nerve cells (NRTX-1001) into both sides of the brain in 10 adults with drug-resistant epilepsy. The cells are designed to calm overactive brain signals by releasing GABA. The main goal is safety, but researchers will also track whether seizures become less frequent.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
NRTX-1001 (inhibitory nerve cells that produce GABA)
What this could lead to
If successful, this could point toward a new treatment that reduces or stops seizures without needing daily medication.
What could go wrong
This is an early, small trial with only 10 participants, so results may not apply to everyone. The procedure involves brain injections, which carry risks like bleeding or infection.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Locations
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Atrium Health
RECRUITINGCharlotte, North Carolina, 28204, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Duke University Hospital
RECRUITINGDurham, North Carolina, 27710, United States
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Medical College of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Oregon Health and Science University
RECRUITINGPortland, Oregon, 97239, United States
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SUNY Upstate Medical University
RECRUITINGSyracuse, New York, 13210, United States
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Stanford University
RECRUITINGPalo Alto, California, 94304, United States
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UC Irvine Medical Center
RECRUITINGOrange, California, 92868, United States
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UTHealth Houston
RECRUITINGHouston, Texas, 77030, United States
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UVA Health University Medical Center
RECRUITINGCharlottesville, Virginia, 22903, United States
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University of Arkansas for Medical Sciences
RECRUITINGLittle Rock, Arkansas, 72205, United States
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University of California San Diego
RECRUITINGSan Diego, California, 92037, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California San Francisco
WITHDRAWNSan Francisco, California, 94143, United States
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University of Chicago
RECRUITINGChicago, Illinois, 60637, United States
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University of Colorado Anschutz Medical Campus
RECRUITINGAurora, Colorado, 80045, United States
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University of Iowa Health Care
RECRUITINGIowa City, Iowa, 52242, United States
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University of Southern California Keck Hospital
RECRUITINGLos Angeles, California, 90033, United States
Contact
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Wake Forest Baptist Medical Center
RECRUITINGWinston-Salem, North Carolina, 27157, United States
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