Brain cell injection could tame epilepsy seizures

NCT ID NCT06422923

Recruiting now Disease control Sponsor: Neurona Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial tests a one-time injection of special nerve cells (NRTX-1001) into both sides of the brain in 10 adults with drug-resistant epilepsy. The cells are designed to calm overactive brain signals by releasing GABA. The main goal is safety, but researchers will also track whether seizures become less frequent.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: NRTX-1001 (inhibitory nerve cells that produce GABA)
What this could lead to: If successful, this could point toward a new treatment that reduces or stops seizures without needing daily medication.
What could go wrong: This is an early, small trial with only 10 participants, so results may not apply to everyone. The procedure involves brain injections, which carry risks like bleeding or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

mesial temporal lobe epilepsy with hippocampal sclerosis temporal lobe epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EPILEPSY, TEMPORAL LOBE

Contacts and locations

Locations

Atrium Health
RECRUITING

Charlotte, North Carolina, 28204, United States
Duke University Hospital
RECRUITING

Durham, North Carolina, 27710, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States
SUNY Upstate Medical University
RECRUITING

Syracuse, New York, 13210, United States
Stanford University
RECRUITING

Palo Alto, California, 94304, United States
UC Irvine Medical Center
RECRUITING

Orange, California, 92868, United States
UTHealth Houston
RECRUITING

Houston, Texas, 77030, United States
UVA Health University Medical Center
RECRUITING

Charlottesville, Virginia, 22903, United States
University of Arkansas for Medical Sciences
RECRUITING

Little Rock, Arkansas, 72205, United States
University of California San Diego
RECRUITING

San Diego, California, 92037, United States
University of California San Francisco
WITHDRAWN

San Francisco, California, 94143, United States
University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States
University of Colorado Anschutz Medical Campus
RECRUITING

Aurora, Colorado, 80045, United States
University of Iowa Health Care
RECRUITING

Iowa City, Iowa, 52242, United States
University of Southern California Keck Hospital
RECRUITING

Los Angeles, California, 90033, United States
Wake Forest Baptist Medical Center
RECRUITING

Winston-Salem, North Carolina, 27157, United States

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