New pill combo offers hope for older leukemia patients who Can't handle chemo

NCT ID NCT07507760

Recruiting now Disease control Sponsor: PETHEMA Foundation Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 30, 2026 · Updated 2 times

Summary

This study tests whether taking two oral medications (decitabine and ivosidenib) together can control acute myeloid leukemia (AML) in patients aged 60+ or those too frail for standard chemo. About 50 participants will take the pills in 28-day cycles until the disease worsens or side effects become too severe. The goal is to achieve complete remission, but treatment is lifelong, so this is about disease control, not a cure.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA WITH GENE MUTATIONS

Contacts and locations

Locations

Complejo Hospitalario Regional Reina Sofía
RECRUITING

Córdoba, 14004, Spain
Complejo Hospitalario de Albacete
NOT_YET_RECRUITING

Albacete, 02006, Spain
Fundación Jiménez Díaz
NOT_YET_RECRUITING

Madrid, 28040, Spain
H. 12 de Octubre
NOT_YET_RECRUITING

Madrid, Spain
H. Dr. Peset
NOT_YET_RECRUITING

Valencia, Spain
Hospital General Universitario Dr. Balmis
NOT_YET_RECRUITING

Alicante, Spain
Hospital San Pedro Alcántara
RECRUITING

Cáceres, Spain
Hospital Univeristario Ramón y Cajal
NOT_YET_RECRUITING

Madrid, Spain
Hospital Universitari i Politècnic La Fe
RECRUITING

Valencia, Spain
Hospital Universitario Lucus Augusti
NOT_YET_RECRUITING

Lugo, Spain
Hospital Universitario Virgen Del Rocío
NOT_YET_RECRUITING

Seville, Spain
Hospital Universitario de Burgos
NOT_YET_RECRUITING

Burgos, 09006, Spain
Hospital Universitario de Canarias
NOT_YET_RECRUITING

Las Palmas de Gran Canaria, Spain
Hospital Universitario de Gran Canaria Doctor Negrín
NOT_YET_RECRUITING

Las Palmas, Spain
Hospital Virgen de la Victoria
RECRUITING

Málaga, Spain

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