New combo therapy for rare blood cancers put on hold

NCT ID NCT06661915

Terminated Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial compares a drug combo (ASTX727 plus iadademstat) against ASTX727 alone for people with advanced myeloproliferative neoplasms (MPNs), a group of rare blood cancers. The study aims to see if adding iadademstat improves complete response rates. However, the trial is currently suspended, and only 62 participants were planned.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

ASTX727 (decitabine and cedazuridine) with or without iadademstat

What this could lead to

If successful, this could point toward a more effective treatment for advanced myeloproliferative neoplasms, potentially improving response rates.

What could go wrong

This is an early-phase trial with only 62 participants, currently suspended. The combination may not prove more effective than ASTX727 alone, and side effects are unknown.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

acquired polycythemia vera atypical chronic myeloid leukemia, BCR-ABL1 negative blast phase chronic myelogenous leukemia, BCR-ABL1 positive essential thrombocythemia leukemia, myeloid, accelerated-phase myelodysplastic/myeloproliferative disease myelodysplastic/myeloproliferative neoplasm myelofibrosis Myeloproliferative Disorders myeloproliferative neoplasm myeloproliferative neoplasm, unclassifiable primary myelofibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACCELERATED PHASE MYELOPROLIFERATIVE NEOPLASM BLAST PHASE MYELOPROLIFERATIVE NEOPLASM ESSENTIAL THROMBOCYTHEMIA MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASM MYELOPROLIFERATIVE NEOPLASM, NOT OTHERWISE SPECIFIED POLYCYTHEMIA VERA PRIMARY MYELOFIBROSIS SECONDARY MYELOFIBROSIS

Contacts and locations

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Locations

Atrium Health Cabarrus/LCI-Concord

Concord, North Carolina, 28025, United States
Carolinas Medical Center/Levine Cancer Institute

Charlotte, North Carolina, 28203, United States
Huntsman Cancer Institute/University of Utah

Salt Lake City, Utah, 84112, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
NYP/Weill Cornell Medical Center

New York, New York, 10065, United States
Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States
Oregon Health and Science University

Portland, Oregon, 97239, United States
Stanford Cancer Institute Palo Alto

Palo Alto, California, 94304, United States
UC Comprehensive Cancer Center at Silver Cross

New Lenox, Illinois, 60451, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, 92868, United States
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care

Irvine, California, 92612, United States
UChicago Medicine Northwest Indiana

Crown Point, Indiana, 46307, United States
UM Sylvester Comprehensive Cancer Center at Coral Gables

Coral Gables, Florida, 33146, United States
UM Sylvester Comprehensive Cancer Center at Coral Springs

Coral Springs, Florida, 33065, United States
UM Sylvester Comprehensive Cancer Center at Deerfield Beach

Deerfield Beach, Florida, 33442, United States
UM Sylvester Comprehensive Cancer Center at Doral

Doral, Florida, 33166, United States
UM Sylvester Comprehensive Cancer Center at Hollywood

Hollywood, Florida, 33021, United States
UM Sylvester Comprehensive Cancer Center at Kendall

Miami, Florida, 33176, United States
UM Sylvester Comprehensive Cancer Center at Plantation

Plantation, Florida, 33324, United States
University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637, United States
University of Chicago Medicine-Orland Park

Orland Park, Illinois, 60462, United States
University of Kansas Cancer Center

Kansas City, Kansas, 66160, United States
University of Kansas Clinical Research Center

Fairway, Kansas, 66205, United States
University of Kansas Hospital-Indian Creek Campus

Overland Park, Kansas, 66211, United States
University of Kansas Hospital-Westwood Cancer Center

Westwood, Kansas, 66205, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center

Miami, Florida, 33136, United States
University of Miami Sylvester Comprehensive Cancer Center at Sole Mia

North Miami, Florida, 33181, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
VCU Massey Comprehensive Cancer Center

Richmond, Virginia, 23298, United States
Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232, United States