Cure My Disease

Don't miss your cure!

 Log in / Sign up

Less therapy, better knees? mayo clinic tests Hands-Off rehab after replacement

NCT ID NCT07879014

Symptom relief Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Oct 16, 2026 · Last updated Oct 16, 2026

Summary

Researchers at Mayo Clinic are comparing two rehabilitation approaches after total knee replacement. One group follows a standard protocol with physical therapy starting days after surgery. The other group follows a 'Quiet Knee Protocol' that delays physical therapy for two weeks, using only active range of motion exercises. The trial measures knee motion at six weeks and tracks pain, opioid use, additional procedures, and patient satisfaction over 12 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a rehabilitation protocol that delays physical therapy for two weeks after knee replacement surgery
What this could lead to
If the Quiet Knee Protocol works, patients might recover with less formal physical therapy, saving time and money while still regaining knee function.
What could go wrong
Delaying physical therapy could slow recovery or lead to stiffness, and the trial may show no difference from standard care. Results may not apply to people with prior knee surgery or other joint problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 170 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults (≥18 years) undergoing unilateral primary TKA for osteoarthritis * Willingness to adhere to the assigned rehabilitation protocol * Ability to provide informed consent Exclusion Criteria: * Revision TKA or bilateral procedures * Preexisting neuromuscular disorders affecting mobility * Prior knee surgery within 12 months * No Joint Hardware * Agree to avoid plane trips post-surgery for 2 weeks * Patients with 100-degree flexion contracture * Pregnant subjects

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Knee osteoarthritis are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Rehabilitation exercise

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hospital for Special Surgery

    NOT_YET_RECRUITING

    New York, New York, 10021, United States

  • Mayo Clinic

    RECRUITING

    Jacksonville, Florida, 32224, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.