New drug could stop knee infections after replacement
NCT ID NCT07214311
First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 2 times
Summary
This study tests whether an investigational drug called PLG0206 can prevent infections from coming back after knee replacement surgery. About 240 adults who need a special cleaning surgery (DAIR) for an infected knee joint will receive either PLG0206 or a placebo during the procedure. Researchers will track them for one year to see if the drug reduces the need for further surgeries or other treatments.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
PLG0206 (an investigational drug used as an irrigation solution during surgery)
What this could lead to
If it works, this could provide a new way to prevent repeat infections after knee replacement surgery, reducing the need for additional surgeries.
What could go wrong
This is an early-to-mid-stage trial with only 240 participants, so results may not apply to everyone. The drug is still experimental, and its safety and effectiveness are not yet proven.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Clinical Trial Site
RECRUITINGSarasota, Florida, 34239, United States
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Clinical Trial Site
RECRUITINGTamarac, Florida, 33321, United States
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Clinical Trial Site
RECRUITINGBaltimore, Maryland, 21215, United States
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Clinical Trial Site
RECRUITINGBoston, Massachusetts, 02120, United States
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Clinical Trial Site
RECRUITINGNew York, New York, 10032, United States
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Clinical Trial Site
RECRUITINGLeland, North Carolina, 28451, United States
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Clinical Trial Site
RECRUITINGCincinnati, Ohio, 45267, United States
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Clinical Trial Site
RECRUITINGColumbus, Ohio, 43210, United States
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Clinical Trial Site
RECRUITINGPittsburgh, Pennsylvania, 15232, United States
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Clinical Trial Site
RECRUITINGDallas, Texas, 75390, United States
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Clinical Trial Site
RECRUITINGEdinburg, Texas, 78539, United States
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Clinical Trial Site
RECRUITINGMorgantown, West Virginia, 26506, United States