New drug aims to keep AML away after transplant

NCT ID NCT05429632

Recruiting now Disease control Sponsor: Priothera SAS Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial tests whether mocravimod, taken as a pill, can prevent acute myeloid leukemia (AML) from returning after a stem cell transplant. About 366 adults with high-risk AML will receive either mocravimod or a placebo for up to two years. The main goal is to see if the drug improves relapse-free survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

mocravimod

What this could lead to

If it works, mocravimod could help prevent AML from coming back after a stem cell transplant, improving long-term survival.

What could go wrong

This is still an experimental drug. Even in this large Phase 3 trial, it may not work better than placebo, and side effects are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADULT ACUTE MYELOID LEUKEMIA

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Anjo-kosei Hospital
WITHDRAWN

Anjo-shi, Aichi-ken, 446-8602, Japan
Apteka NSSU
WITHDRAWN

Krakow, 31-501, Poland
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo Alessandria
WITHDRAWN

Alessandria, 15121, Italy
Azienda Ospedaliera Ospedali Riuniti Marche Nord
RECRUITING

Pesaro, 61122, Italy

Contact Email: •••••@•••••
Azienda Ospedaliera San Gerardo - Monza
RECRUITING

Monza, 20900, Italy

Contact Email: •••••@•••••
Azienda Sanitaria Locale 13 - Ospedale "C. e G. Mazzoni"- Ascoli Piceno
ACTIVE_NOT_RECRUITING

Ascoli Piceno, 63100, Italy
Azienda Sanitaria Localedella provincia di Brindisi -
WITHDRAWN

Brindisi, 72100, Italy
Banner MD Anderson Cancer Center
WITHDRAWN

Gilbert, Arizona, 85234-2165, United States
Baylor Charles A. Sammons Cancer Center
RECRUITING

Dallas, Texas, 75246, United States

Contact Email: •••••@•••••
CEPON - Centro de Pesquisas Oncologicas
WITHDRAWN

Florianópolis, Santa Catarina, 88034-000, Brazil
CHRU Nancy Hopitaux de Brabois
RECRUITING

Nancy, France

Contact Email: •••••@•••••
CHU de Nantes - Hôtel Dieu
ACTIVE_NOT_RECRUITING

Nantes, France
Centralny Szpital Kliniczny Apteka Szpitalna
RECRUITING

Warsaw, 02-097, Poland

Contact Email: •••••@•••••
Centre Hospitalier Lyon-Sud
RECRUITING

Lyon, 69495, France

Contact Email: •••••@•••••
Centre Hospitalier Regional Universitaire (CHRU) de Lille - Hopital Claude Huriez -
ACTIVE_NOT_RECRUITING

Lille, France
Centre Hospitalier Universitaire (CHU) Angers
RECRUITING

Angers, France

Contact Email: •••••@•••••
Centre de Lutte Contre le Cancer (CLCC) - Institut Gustave-Roussy
RECRUITING

Villejuif, France

Contact Email: •••••@•••••

Contact
Centro de Educacion Medica E Investigacines Clinicas Norberto Quirno CEMIC
RECRUITING

Buenos Aires, Argentina

Contact Email: •••••@•••••
Changhua Christian Hospital
WITHDRAWN

Changhua, 500, Taiwan
City of Hope Comprehensive Cancer Center - Duarte
RECRUITING

Duarte, California, 91010, United States

Contact Email: •••••@•••••
Ehime Prefectural Centeral Hospital, Ehime
WITHDRAWN

Matsuyama, 790-0024, Japan
Emory University - Winship Cancer Institute (WCI)
RECRUITING

Atlanta, Georgia, 30322-1013, United States

Contact Email: •••••@•••••
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
RECRUITING

Milan, Italy

Contact Email: •••••@•••••
Fondazione IRCCS Policlinico San Matteo
RECRUITING

Pavia, 27100, Italy

Contact Email: •••••@•••••
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
RECRUITING

Roma, 00168, Italy

Contact Email: •••••@•••••
Grande Ospedale Metropolitano Bianchi Melacrino Morelli
RECRUITING

Reggio Calabria, Calabria, 89133, Italy

Contact Email: •••••@•••••
Hadassah Medical Center
RECRUITING

Jerusalem, Israel

Contact Email: •••••@•••••
Henry Ford Cancer Institute
RECRUITING

Detroit, Michigan, 48202-2610, United States

Contact Email: •••••@•••••
Hiroshima Red Cross Hospital & Atomic-Bomb Survivors Hospital
ACTIVE_NOT_RECRUITING

Hiroshima, 730-8619, Japan
Hokkaido University Hospital
RECRUITING

Sapporo, 060-8648, Japan

Contact Email: •••••@•••••
Hospital Alemao Oswaldo Cruz (HAOC)
RECRUITING

São Paulo, 01327-001, Brazil

Contact Email: •••••@•••••
Hospital Amaral Carvalho
RECRUITING

São Paulo, 17210-080, Brazil

Contact Email: •••••@•••••
Hospital Clinico Universitario - Universidad de Salamanca
RECRUITING

Salamanca, Spain

Contact Email: •••••@•••••
Hospital De La Princesa
WITHDRAWN

Madrid, Spain
Hospital El Cruce - Dr. Nestor Kirchner
RECRUITING

Buenos Aires, B1884LAD, Argentina

Contact Email: •••••@•••••
Hospital Erasto Gaertner
RECRUITING

Curicica, 81520-060, Brazil

Contact Email: •••••@•••••
Hospital Israelita Albert Einstein
ACTIVE_NOT_RECRUITING

São Paulo, 05652-900, Brazil
Hospital Italiano La Plata
RECRUITING

La Plata, 1900, Argentina

Contact Email: •••••@•••••
Hospital Saint Antoine
RECRUITING

Paris, France

Contact Email: •••••@•••••
Hospital Universitari Vall d'Hebron - Institut de Recerca (VHIR)
RECRUITING

Barcelona, 08035, Spain

Contact Email: •••••@•••••
Hospital Universitari i Politecnic La Fe
RECRUITING

Valencia, Spain

Contact Email: •••••@•••••
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, Spain

Contact Email: •••••@•••••
Hospital Universitario Ramon y Cajal
RECRUITING

Madrid, Spain

Contact Email: •••••@•••••
Hospital Universitario Virgen de las Nieves
RECRUITING

Granada, Spain

Contact Email: •••••@•••••
Hospital Universitario de Gran Canaria ""
RECRUITING

Las Palmas de Gran Canaria, Spain

Contact Email: •••••@•••••
Hôpital Saint Louis
ACTIVE_NOT_RECRUITING

Paris, France
Imperial College, London
ACTIVE_NOT_RECRUITING

London, United Kingdom
Institut Catala d'Oncologia (ICO)
RECRUITING

Barcelona, 8908, Spain

Contact Email: •••••@•••••

Contact
Institut Catala d'Oncologia (ICO) - Hospital Universitari Germans Trias i Pujol (HUGTP) Location
WITHDRAWN

Barcelona, 8916, Spain
Institut Universitaire du Cancer de Toulouse Oncopole
ACTIVE_NOT_RECRUITING

Toulouse, 31059, France
Institutul Clinic Fundeni
RECRUITING

Bucharest, 022328, Romania

Contact Phone: •••-•••-•••• Email: •••••@•••••
Institutul Regional de Oncologie Iasi, - Haematology Department
WITHDRAWN

Iași, 700483, Romania
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale Casa Sollievo della Sofferenza (CSS)
ACTIVE_NOT_RECRUITING

San Giovanni Rotondo, Foggia, 71013, Italy
Japanese Red Cross Nagoya Daiichi Hospital (First Hospital)
RECRUITING

Nagoya, Aichi-ken, 466-8550, Japan

Contact Email: •••••@•••••
Jichi Medical University (JMU) Hospital
WITHDRAWN

Shimotsuke-shi, Tochigi, 329-0498, Japan
Jichi Medical University Saitama Medical Center
WITHDRAWN

Saitama, 330-8503, Japan
Kanazawa University Hospital
WITHDRAWN

Kanazawa, Ishikawa-ken, 920-8541, Japan
Kobe City Medical Center General Hospital
ACTIVE_NOT_RECRUITING

Kobe, 650-0047, Japan
Kyoto University Hospital
ACTIVE_NOT_RECRUITING

Kōtoku, 606-8507, Japan
Kyushu University Hospital,
RECRUITING

Fukuoka, 812-8582, Japan

Contact Email: •••••@•••••
LMU Klinikum Grosshadern Klinikum der Universitaet Muenchen
ACTIVE_NOT_RECRUITING

Munich, 81377, Germany
Manchester Royal Infirmary;Manchester University
RECRUITING

Manchester, M139WL, United Kingdom

Contact Email: •••••@•••••
Massachusetts General Hospital
WITHDRAWN

Boston, Massachusetts, 02114, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States

Contact Email: •••••@•••••
National Cheng-Kung University Hospital
WITHDRAWN

Tainan, 70403, Taiwan
National Taiwan University Cancer Center
RECRUITING

Taipei, 106, Taiwan

Contact Phone: •••-•••-•••• Email: •••••@•••••
National Taiwan University Hospital (NTUH)
RECRUITING

Taipei, 10002, Taiwan

Contact Phone: •••-•••-•••• Email: •••••@•••••
Newcastle Upon Tyne Hospitals Norhtern Center for Cancer Care
RECRUITING

Newcastle upon Tyne, NE7 7DN, United Kingdom

Contact Email: •••••@•••••
Nottingham University Hospitals NHS Trust
ACTIVE_NOT_RECRUITING

Nottingham, NG5 1PB, United Kingdom
Ochsner Medical Center (OMC) - New Orleans
WITHDRAWN

New Orleans, Louisiana, 70121, United States
Oita University (OU) Hospital
WITHDRAWN

Yufu, 875593, Japan
Okayama University Hospital
ACTIVE_NOT_RECRUITING

Okayama, 700-8558, Japan
Oregon Health & Science University (OHSU) - Knight Cancer Institute
RECRUITING

Portland, Oregon, 97239-3098, United States

Contact Email: •••••@•••••
Osaka Metropolitan University Hospital
RECRUITING

Osaka, Osaka, 545-8589, Japan

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••
Ospedale Vito Fazzi Lecce
RECRUITING

Lecce, 73100, Italy

Contact Email: •••••@•••••
Oxford University Hospitals
RECRUITING

Oxford, United Kingdom

Contact Email: •••••@•••••
Queen Elizabeth Hospital
RECRUITING

Birmingham, B152TH, United Kingdom

Contact Email: •••••@•••••
Queen Elizabeth University Hospital
RECRUITING

Glasgow, G514TF, United Kingdom

Contact Email: •••••@•••••
Rambam Health Care Campus
RECRUITING

Haifa, Israel

Contact Email: •••••@•••••
Royal Hallamshire Hospital
RECRUITING

Sheffield, S10 2JF, United Kingdom

Contact Email: •••••@•••••
Sanatorio Allende (SA) - Nueva Cordoba
WITHDRAWN

Córdoba, Argentina
Slaski Uniwersytet Medyczny (SUM) w Katowicach - Samodzielny Publiczny Szpital Kliniczny im. Andrzeja Mieleckiego (SPSKM) - Slaskie Centrum Hematologii I Transplantacji Szpiku
ACTIVE_NOT_RECRUITING

Katowice, Silesian Voivodeship, Silesia, Poland
Sp Zoz Szpital Uniwersytecki W Krakowie
WITHDRAWN

Krakow, Aichi-Ken, 30-688, Poland
Spectrum Health Medical Group (SHMG) - Blood & Marrow Transplant - Adult (BMT)
ACTIVE_NOT_RECRUITING

Grand Rapids, Michigan, 49503, United States
Spitalul Clinic Coltea
WITHDRAWN

Bucharest, Romania
Stony Brook University (SBU) - Cancer Center
ACTIVE_NOT_RECRUITING

Stony Brook, New York, 11794-0001, United States
Strasbourg (UIC d'onco-hématologie - Hôpital de Hautepierre)
NOT_YET_RECRUITING

Strasbourg, France

Contact Email: •••••@•••••
The Chaim Sheba Medical Center
RECRUITING

Tel Litwinsky, Israel

Contact Email: •••••@•••••
The Ohio State University Comprehensive Cancer Center (OSUCCC)
RECRUITING

Cleveland, Ohio, 44106-1716, United States

Contact Email: •••••@•••••
The Tel Aviv Sourasky Medical Center
RECRUITING

Tel Aviv, Israel

Contact Email: •••••@•••••
Tokyo Metropolitan Cancer and infection Disese Center Komagome Hospital
ACTIVE_NOT_RECRUITING

Tokyo, Japan
UCHealth Cancer Care - Anschutz Medical Campus - University of Colorado Cancer Center
WITHDRAWN

Aurora, Colorado, 80045, United States
Unicamp
RECRUITING

São Paulo, 13083-878, Brazil

Contact Email: •••••@•••••
Universidade de Sao Paulo (USP) - Hospital das Clinicas da Faculdade de Medicina (HCFMUSP)
RECRUITING

São Paulo, 05403-000, Brazil

Contact Email: •••••@•••••
Universita degli Studi di Firenze - Azienda Ospedaliero-Universitaria Careggi (AOUC) LAB TMO
RECRUITING

Florence, Italy

Contact Email: •••••@•••••
Universitaetsklinikum Jena - Klinik fuer Innere Medizin II
WITHDRAWN

Jena, 07747, Germany
Universitaetsspital Basel
RECRUITING

Basel, Switzerland

Contact Email: •••••@•••••
University College Hospital,
RECRUITING

London, NW1 2BU, United Kingdom

Contact Email: •••••@•••••
University Hospital of Wales, Cardiff
RECRUITING

Cardiff, CF14 4XW, United Kingdom

Contact Email: •••••@•••••
University of Alabama Hospital (UAB Hospital)
ACTIVE_NOT_RECRUITING

Birmingham, Alabama, 35233-1932, United States
University of California Los Angeles (UCLA) - David Geffen School of Medicine
RECRUITING

Los Angeles, California, 90095, United States

Contact Email: •••••@•••••
University of Cincinnati Medical Center (University Hospital)
RECRUITING

Cincinnati, Ohio, 45267, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••
University of Iowa Hospitals and Clinics
RECRUITING

Iowa City, Iowa, 52242, United States

Contact Email: •••••@•••••
University of Kansas Cancer Center
RECRUITING

Westwood, Kansas, 66103, United States

Contact Email: •••••@•••••
University of Leipzig Medical Center
ACTIVE_NOT_RECRUITING

Leipzig, 04103, Germany
University of Maryland Medical Center (UMMC)
RECRUITING

Baltimore, Maryland, 21201-1544, United States

Contact Email: •••••@•••••
University of Pennsylvania - Abramson Cancer Center
SUSPENDED

Philadelphia, Pennsylvania, 19104-4206, United States
University of Rochester Medical Center (URMC)
RECRUITING

Rochester, New York, 14642, United States

Contact Email: •••••@•••••
Universitätsklinikum Halle
RECRUITING

Halle, Germany

Contact Email: •••••@•••••
Uniwersyteckie Centrum Kliniczne (UCK)
RECRUITING

Gdansk, 80-952, Poland

Contact Email: •••••@•••••

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