New triple therapy aims to boost survival in frail AML patients
NCT ID NCT07478991
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 3 trial will test whether adding the drug quizartinib to the standard two-drug combination (venetoclax and azacitidine) helps adults with newly diagnosed acute myeloid leukemia (AML) live longer. The study includes 376 people aged 18 and older who cannot receive intensive chemotherapy due to age or health problems. Participants will be randomly assigned to receive either the standard two drugs or the three-drug combination, and researchers will compare survival rates between the groups.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Quizartinib (added to venetoclax and azacitidine)
- What this could lead to
- If successful, this could offer a more effective treatment option for older or frail adults with acute myeloid leukemia, potentially improving survival without needing intensive chemotherapy.
- What could go wrong
- This is an early-stage phase 3 trial that has not yet started recruiting. Adding a third drug may increase side effects, and it is not yet known if the combination will actually improve outcomes compared to the current standard.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Locations
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Clínica Universitaria de Navarra
Pamplona, Spain
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Complejo Hospitalario Regional Reina Sofía
Córdoba, 14004, Spain
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Complejo Hospitalario Universitario Insular-Materno Infantil
Las Palmas de Gran Canaria, Spain
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Complejo Hospitalario Universitario Nuestra Señora de la Candelaria
Santa Cruz de Tenerife, 38010, Spain
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Complejo Hospitalario Universitario de A Coruña
Santiago de Compostela, A Coruña, 15706, Spain
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Complejo Hospitalario de Albacete
Albacete, 02006, Spain
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Complejo Hospitalario de Cáceres
Cáceres, Spain
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Complejo Hospitalario de Gran Canaria Dr. Negrin
Las Palmas de Gran Canaria, Spain
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Complejo Hospitalario de Jaén
Jaén, Jaen, 23007, Spain
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Fundación Jiménez Díaz
Madrid, Spain
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H. Dr. Peset
Valencia, Spain
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H. General de Castellón
Castelló, Spain
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H. Marqués de Valdecilla
Santander, Spain
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H. Río Hortega
Valladolid, Spain
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H.U. Puerta de Hierro Majadahonda
Majadahonda, Spain
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HLA Hospital Universitario Moncloa
Madrid, Spain
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HU Quirónsalud Madrid
Madrid, Spain
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Hospital Arnau de Vilanova-Valencia
Valencia, Spain
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Hospital Clinico Universitario Virgen de La Arrixaca
Murcia, Spain
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Hospital Clínico San Carlos
Madrid, Spain
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Hospital Clínico Universitario de Salamanca.
Salamanca, Spain
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Hospital Galdakao-Usansolo
Barakaldo, Spain
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Hospital General Universitario Dr. Balmis
Alicante, Spain
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Hospital General Universitario de Toledo
Toledo, Spain
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Hospital General de Segovia
Segovia, Spain
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Hospital General de Valencia
Valencia, Spain
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Hospital Infanta Leonor
Madrid, Spain
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Hospital Mútua de Terrassa
Terrassa, Barcelona, Spain
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Hospital Principe de Asturias
Alcalá de Henares, Madrid, Spain
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Hospital Regional Universitario de Málaga
Málaga, Malaga, 29010, Spain
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Hospital Univeristario Ramón y Cajal
Madrid, Spain
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Hospital Universitari i Politècnic La Fe
Valencia, Spain
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Hospital Universitario Donostia
Donostia / San Sebastian, Spain
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Hospital Universitario HM Sanchinarro
Madrid, Spain
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Hospital Universitario Infanta Sofía
San Sebastián de los Reyes, Madrid, 28702, Spain
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Hospital Universitario Juan Ramón Jiménez
Huelva, 21005, Spain
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Hospital Universitario Lucus Augusti
Lugo, Spain
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Hospital Universitario Puerta del Mar
Cadiz, Spain
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Hospital Universitario Torrecárdenas
Almería, Spain
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Hospital Universitario Virgen Del Rocío
Seville, Spain
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Hospital Universitario Virgen de Valme
Seville, Spain
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Hospital Universitario Virgen de la Victoria
Málaga, Spain
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Hospital Universitario de Basurto
Barakaldo, Spain
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Hospital Universitario de Burgos
Burgos, Spain
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Hospital Universitario de Canarias
Las Palmas de Gran Canaria, Spain
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Hospital Universitario de Cruces
Barakaldo, Vizcaya, 48903, Spain
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Hospital Virgen Del Puerto
Plasencia, Spain
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Hospital de Santiago de Compostela
Santiago de Compostela, Spain
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Hospital Álvaro Cunqueiro
Vigo, Spain
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ICO Hospitalet- Hospital Duran i Reynals
Hospitalet Del Llobregat, Barcelona, 08908, Spain
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Institut Catalá d´Oncología (ICO Badalona)
Badalona, Spain
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