New pill combo aims to tackle tough leukemia
NCT ID NCT05133882
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing a new targeted drug called crifortinib besylate (taken as a pill) combined with standard chemotherapy in adults who have just been diagnosed with acute myeloid leukemia (AML). The trial has two phases: first, finding the best dose, then testing it in a larger group, especially in patients with a specific genetic change (FLT3 mutation). About 133 people will take part. The goal is to see if the combination helps control the disease better than chemo alone.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- crifortinib besylate (a targeted cancer drug taken as a pill)
- What this could lead to
- If successful, this combination could offer a new treatment option for adults with acute myeloid leukemia, especially those with a FLT3 mutation.
- What could go wrong
- This is an early-phase trial (phase 1/2) with a small number of participants, so the drug may not prove effective or safe enough for wider use. Side effects from the drug or chemotherapy are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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the First Affiliated Hospital,College of Medicine,Zhejiang University
RECRUITINGHanzhou, Zhejiang, 310003, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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