New pill combo aims to tackle tough leukemia

NCT ID NCT05133882

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing a new targeted drug called crifortinib besylate (taken as a pill) combined with standard chemotherapy in adults who have just been diagnosed with acute myeloid leukemia (AML). The trial has two phases: first, finding the best dose, then testing it in a larger group, especially in patients with a specific genetic change (FLT3 mutation). About 133 people will take part. The goal is to see if the combination helps control the disease better than chemo alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
crifortinib besylate (a targeted cancer drug taken as a pill)
What this could lead to
If successful, this combination could offer a new treatment option for adults with acute myeloid leukemia, especially those with a FLT3 mutation.
What could go wrong
This is an early-phase trial (phase 1/2) with a small number of participants, so the drug may not prove effective or safe enough for wider use. Side effects from the drug or chemotherapy are possible.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • the First Affiliated Hospital,College of Medicine,Zhejiang University

    RECRUITING

    Hanzhou, Zhejiang, 310003, China

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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