Can a targeted pill boost standard therapy for hard-to-treat leukemia?

NCT ID NCT06652438

Recruiting now Disease control Sponsor: Stichting Hemato-Oncologie voor Volwassenen Nederland Source: ClinicalTrials.gov ↗

First seen Jul 29, 2026 · Last updated Aug 05, 2026 · Updated 4 times

Summary

This phase 3 trial is testing whether adding revumenib, a drug that blocks a protein called menin, to the usual two-drug combination (azacitidine and venetoclax) can improve outcomes for adults newly diagnosed with acute myeloid leukemia (AML) that has a specific genetic change (NPM1 mutation or KMT2A rearrangement). The study enrolls people who are not healthy enough for intensive chemotherapy. Participants are randomly assigned to receive either revumenib or a placebo alongside standard treatment, and researchers will track survival and remission rates over several years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: revumenib added to azacitidine and venetoclax
What this could lead to: If successful, this could lead to a more effective treatment option for people with certain genetic types of AML who cannot tolerate intensive chemotherapy.
What could go wrong: This is an early-phase trial, and the added drug may cause more side effects or fail to improve survival. Results will take years to confirm.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia acute myeloid leukemia with mutated NPM1 acute myeloid leukemia, MLL gene rearrangement

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA, ADULT

Contacts and locations

Locations

AT-Feldkirch-IKHF
NOT_YET_RECRUITING

Feldkirch, Austria
AT-Linz-KEPLER
NOT_YET_RECRUITING

Linz, Austria
AT-Salzburg-SALK
NOT_YET_RECRUITING

Salzburg, Austria
AT-Vienna-HANUSCH
NOT_YET_RECRUITING

Vienna, Austria
AU-Adelaide-RAH
NOT_YET_RECRUITING

Adelaide, Australia
AU-Birtinya-SUNSHINECOASTUH General Information
NOT_YET_RECRUITING

Birtinya, Australia
AU-Brisbane-RBWH
NOT_YET_RECRUITING

Brisbane, Australia
AU-Douglas-TOWNSVILLE
NOT_YET_RECRUITING

Douglas, Australia
AU-Melbourne-ALFRED
NOT_YET_RECRUITING

Melbourne, Australia
AU-Melbourne-MONASH
NOT_YET_RECRUITING

Melbourne, Australia
AU-Perth-FSH
WITHDRAWN

Perth, Australia
AU-Perth-SCGH
NOT_YET_RECRUITING

Perth, Australia
AU-Sydney-RNSH
NOT_YET_RECRUITING

Sydney, Australia
AU-Sydney-SVSH
NOT_YET_RECRUITING

Sydney, Australia
Amsterdamumc
RECRUITING

Amsterdam, Netherlands
BE-Antwerpen-ZAS
RECRUITING

Antwerp, Belgium
BE-Brugge-AZBRUGGE
RECRUITING

Bruges, Belgium
BE-Brussel-BORDET
RECRUITING

Brussels, Belgium
BE-Brussel-UZBRUSSEL
RECRUITING

Brussels, Belgium
BE-Bruxelles-STLUC
RECRUITING

Brussels, Belgium
BE-Gent-UZGENT
RECRUITING

Ghent, Belgium
BE-Hasselt-VIRGAJESSE
NOT_YET_RECRUITING

Hasselt, Belgium
BE-Leuven-UZLEUVEN
RECRUITING

Leuven, Belgium
BE-Liege-CHULIEGE
RECRUITING

Liège, Belgium
BE-Yvoir-MONTGODINNE
RECRUITING

Yvoir, Belgium
Beatson West of Scotland Cancer Centre
RECRUITING

Glasgow, United Kingdom
Belfasttrust
NOT_YET_RECRUITING

Belfast, United Kingdom
Birmingham-QE
NOT_YET_RECRUITING

Birmingham, United Kingdom
Blackpool Victoria
RECRUITING

Blackpool, United Kingdom
CH-Aarau-KSA
RECRUITING

Aarau, Switzerland
CH-Basel-USB
RECRUITING

Basel, Switzerland
CH-Bellinzona-IOSI
RECRUITING

Bellinzona, Switzerland
CH-Bern-INSEL
RECRUITING

Bern, Switzerland
CH-Geneve (14)-HCUGE
RECRUITING

Geneva, Switzerland
CH-Zürich-USZ
NOT_YET_RECRUITING

Zurich, Switzerland
Christie NHS Foundation Trust
RECRUITING

Manchester, United Kingdom
Churchill Hospital, Oxford
RECRUITING

Oxford, United Kingdom
DE-Berlin-CAMPUSBENFRANKLIN
NOT_YET_RECRUITING

Berlin, Germany
DE-Berlin-CAMPUSVIRCHOW
NOT_YET_RECRUITING

Berlin, Germany
DE-Berlin-VIVANTESNEUKOLLN
NOT_YET_RECRUITING

Berlin, Germany
DE-Bochum-RUB
RECRUITING

Bochum, Germany
DE-Bonn-UNIBONN
NOT_YET_RECRUITING

Bonn, Germany
DE-Braunschweig-KLINIKUMBRAUNSCHWEIG
NOT_YET_RECRUITING

Braunschweig, Germany
DE-Bremen-KBM
NOT_YET_RECRUITING

Bremen, Germany
DE-Darmstadt-KLINIKUMDARMSTADT
NOT_YET_RECRUITING

Darmstadt, Germany
DE-Essen-KEM
NOT_YET_RECRUITING

Essen, Germany
DE-Flensburg-MALTESER
RECRUITING

Flensburg, Germany
DE-Freiburg-UNIKLINIKFREIBURG
NOT_YET_RECRUITING

Freiburg im Breisgau, Germany
DE-Greifswald-UNIGREIFSWALD
RECRUITING

Greifswald, Germany
DE-Hamburg-ASKLEPIOSSTGEORG
NOT_YET_RECRUITING

Hamburg, Germany
DE-Hamburg-UKE
NOT_YET_RECRUITING

Hamburg, Germany
DE-Hannover-MHHANNOVER
NOT_YET_RECRUITING

Hanover, Germany
DE-Heilbronn-SLK General Information
RECRUITING

Heilbronn, Germany
DE-Herne-MARIENHOSPITALHERNE
RECRUITING

Herne, Germany
DE-Karlsruhe-KLINIKUMKARLSRUHE
NOT_YET_RECRUITING

Karlsruhe, Germany
DE-Magdeburg-OVGU
RECRUITING

Magdeburg, Germany
DE-Mainz-UNIMEDIZINMAINZ
RECRUITING

Mainz, Germany
DE-Minden-MUEHLENKREISKLINKEN
NOT_YET_RECRUITING

Minden, Germany
DE-München-IRZTUM
NOT_YET_RECRUITING

München, Germany
DE-Oldenburg-KLINIKUMOLDENBURG
NOT_YET_RECRUITING

Oldenburg, Germany
DE-Potsdam-BERGMANN
NOT_YET_RECRUITING

Potsdam, Germany
DE-Regensburg-UKR
NOT_YET_RECRUITING

Regensburg, Germany
DE-Rostock-MUROSTOCK
NOT_YET_RECRUITING

Rostock, Germany
DE-Stuttgart-KLINIKUMSTUTTGART
NOT_YET_RECRUITING

Stuttgart, Germany
DE-Tübingen-MEDUNITUEBINGEN
NOT_YET_RECRUITING

Tübingen, Germany
DE-Ulm-UNIKLINKULM
RECRUITING

Ulm, Germany
DE-Wuppertal-HELIOSGESUNDHEIT
NOT_YET_RECRUITING

Wuppertal, Germany
DK-Aalborg-AALBORGUH
NOT_YET_RECRUITING

Aalborg, Denmark
DK-Aarhus N-AUH
RECRUITING

Aarhus N, Denmark
DK-Copenhagen-RIGSHOSPITALET
NOT_YET_RECRUITING

Copenhagen, Denmark
DK-Odense-OUH
NOT_YET_RECRUITING

Odense, Denmark
EE-Tallinn-REGIONAALHAIGLA
RECRUITING

Tallinn, Estonia
EE-Tartu-TARTU
RECRUITING

Tartu, Estonia
ES-Alicante-BALMIS
NOT_YET_RECRUITING

Alicante, Spain
ES-Barcelona-CLINICUB
RECRUITING

Barcelona, Spain
ES-Barcelona-GERMANTRIALS
RECRUITING

Barcelona, Spain
ES-Barcelona-ICODURANREYNALS
RECRUITING

Barcelona, Spain
ES-Barcelona-MUTUATERRASSA
RECRUITING

Barcelona, Spain
ES-Barcelona-PARCDESALUTMAR
RECRUITING

Barcelona, Spain
ES-Barcelona-SANTPAU
RECRUITING

Barcelona, Spain
ES-Girona-ICOGIRONA
RECRUITING

Girona, Spain
ES-Lleida-ICSVILANOVA
RECRUITING

Lleida, Spain
ES-Madrid-CSGREGORIOMARANON
RECRUITING

Madrid, Spain
ES-Palma-SSIB
RECRUITING

Palma de Mallorca, Spain
ES-Tarragona-JOAN
NOT_YET_RECRUITING

Tarragona, Spain
ES-Valencia-MALVARROSA
RECRUITING

Valencia, Spain
FI-Helsinki-HUS
RECRUITING

Helsinki, Finland
FI-Oulu-OYS
RECRUITING

Oulu, Finland
FI-Tampere-TAYS
RECRUITING

Tampere, Finland
FI-Turku-TYKS
RECRUITING

Turku, Finland
FR-Amiens-CHUAMIENS
NOT_YET_RECRUITING

Amiens, France
FR-Angers-CHUANGERS
NOT_YET_RECRUITING

Angers, France
FR-Bayonne-CHCOTEBASQUE
NOT_YET_RECRUITING

Bayonne, France
FR-Besançon Cedex-JEANMINJOZ
NOT_YET_RECRUITING

Besançon, France
FR-Caen-CHUCAEN
RECRUITING

Caen, France
FR-Clamart-HIAPERCY
RECRUITING

Clamart, France
FR-Clermont Ferrand-ESTAING
NOT_YET_RECRUITING

Clermont-Ferrand, France
FR-Créteil cedex-CHUMONDOR
NOT_YET_RECRUITING

Créteil, France
FR-Grenoble cedex 9-CHUGRENOBLE
RECRUITING

Grenoble, France
FR-Le Chesnay cedex-CHVERSAILLES
NOT_YET_RECRUITING

Le Chesnay, France
FR-Lille-CHULILLE
NOT_YET_RECRUITING

Lille, France
FR-Limoges-CHULIMOGES
NOT_YET_RECRUITING

Limoges, France
FR-Lyon Pierre Benite cedex-LYONSUD
RECRUITING

Pierre-Bénite, France
FR-Metz-Cedex-MERCY
RECRUITING

Metz, France
FR-Montpellier-STELOI
RECRUITING

Montpellier, France
FR-Nantes-CHUNANTES
NOT_YET_RECRUITING

Nantes, France
FR-Nice-LARCHET
NOT_YET_RECRUITING

Nice, France
FR-Pessac Cedex-CHUBORDEAUX
RECRUITING

Pessac, France
FR-Rouen cedex-BECQUEREL
NOT_YET_RECRUITING

Rouen, France
FR-Saint-Priest-en-Jarez-STETIENNE
RECRUITING

Saint-Priest-en-Jarez, France
FR-Strasbourg cedex-HAUTEPIERRE
NOT_YET_RECRUITING

Strasbourg, France
Halle-UMH
RECRUITING

Halle, Germany
IE-Cork-CUH
RECRUITING

Cork, Ireland
IE-Dublin 4-SVUH
RECRUITING

Dublin, Ireland
IE-Dublin 7-MATER
RECRUITING

Dublin, Ireland
IE-Dublin 8-STJAMES
RECRUITING

Dublin, Ireland
IE-Dublin 9-BEAUMONT
RECRUITING

Dublin, Ireland
IE-Galway-UHGALWAY
RECRUITING

Galway, Ireland
IE-Waterford City-WATERFORD
RECRUITING

Waterford, Ireland
IT-Ancona-MARCHE
RECRUITING

Ancona, Italy
IT-Bologna-MALPHIGI
NOT_YET_RECRUITING

Bologna, Italy
IT-Civitanova Marche-AZURZONA
NOT_YET_RECRUITING

Civitanova Marche, Italy
IT-Milano-NIGUARDA
NOT_YET_RECRUITING

Milan, Italy
IT-Pagani-TORTORA
NOT_YET_RECRUITING

Pagani, Italy
IT-Palermo-CERVELLO
NOT_YET_RECRUITING

Palermo, Italy
IT-Perugia-OSPEDALEPERUGIA
NOT_YET_RECRUITING

Perugia, Italy
IT-Pescara-AUSLPESCARA
NOT_YET_RECRUITING

Pescara, Italy
IT-Roma-SAPIENZA
NOT_YET_RECRUITING

Roma, Italy
IT-Roma-TORVERGATA
NOT_YET_RECRUITING

Roma, Italy
IT-Torino-CITTADELLASALUTE
NOT_YET_RECRUITING

Torino, Italy
IT-Trieste-MAGGIORETRIESTE
NOT_YET_RECRUITING

Trieste, Italy
King's College Hospital
RECRUITING

London, United Kingdom
LT-Vilnius-SANTA
RECRUITING

Vilnius, Lithuania
NL-Amersfoort-MEANDERMC
RECRUITING

Amersfoort, Netherlands
NL-Amsterdam-OLVG
RECRUITING

Amsterdam, Netherlands
NL-Arnhem-RIJNSTATE
RECRUITING

Arnhem, Netherlands
NL-Breda-AMPHIA
RECRUITING

Breda, Netherlands
NL-Delft-RDGG
RECRUITING

Delft, Netherlands
NL-Den Bosch-JBZ
RECRUITING

's-Hertogenbosch, Netherlands
NL-Den Haag-HAGA
RECRUITING

The Hague, Netherlands
NL-Dordrecht-ASZ
RECRUITING

Dordrecht, Netherlands
NL-Dordrecht-ASZ
RECRUITING

Dordrecht, Netherlands
NL-Eindhoven-MAXIMAMC
RECRUITING

Eindhoven, Netherlands
NL-Enschede-MST
RECRUITING

Enschede, Netherlands
NL-Goes-ADRZ
RECRUITING

Goes, Netherlands
NL-Groningen-UMCG
RECRUITING

Groningen, Netherlands
NL-Leeuwarden-FRISIUSMC
RECRUITING

Leeuwarden, Netherlands
NL-Leiden-LUMC
RECRUITING

Leiden, Netherlands
NL-Maastricht-MUMC
RECRUITING

Maastricht, Netherlands
NL-Nieuwegein-ANTONIUS
RECRUITING

Nieuwegein, Netherlands
NL-Nijmegen-RADBOUDUMC
RECRUITING

Nijmegen, Netherlands
NL-Rotterdam-ERASMUSMC
RECRUITING

Rotterdam, Netherlands
NL-Utrecht-UMCUTRECHT
RECRUITING

Utrecht, Netherlands
NL-Zwolle-ISALA
RECRUITING

Zwolle, Netherlands
NO-Bergen-HELSEBERGEN
RECRUITING

Bergen, Norway
NO-Drammen-VESTREVIKEN
RECRUITING

Drammen, Norway
NO-Lørenskog-AKERSHUS
NOT_YET_RECRUITING

Lørenskog, Norway
NO-Oslo-OSLOUH
RECRUITING

Oslo, Norway
NO-Stavanger-HELSESTAVANGER
RECRUITING

Stavanger, Norway
NO-Tromsø-NORTHNOORWEGEN
NOT_YET_RECRUITING

Tromsø, Norway
NO-Trondheim-STOLAV
RECRUITING

Trondheim, Norway
New cross hospital wolverhampton
RECRUITING

Wolverhampton, United Kingdom
Nottingham University Hospitals NHS Trust
RECRUITING

Nottingham, United Kingdom
SE-Goteborg-SAHLGRENSKA
RECRUITING

Gothenburg, Sweden
SE-Lund-SUH
RECRUITING

Lund, Sweden
SE-Stockholm-KAROLINSKAHUDDINGE
NOT_YET_RECRUITING

Stockholm, Sweden
SE-Uppsala-UPPSALAUH
RECRUITING

Uppsala, Sweden
Southampton General Hospital
RECRUITING

Southampton, United Kingdom
St Bartholomew's Hospital
RECRUITING

London, United Kingdom
St. James UH
RECRUITING

Leeds, United Kingdom
The Newcastle upon Tyne Hospitals NHS Foundation Trust
RECRUITING

Newcastle, United Kingdom
The Royal Marsden NHSFT
RECRUITING

Sutton, United Kingdom
UK-Bodelwyddan-BCUHB
NOT_YET_RECRUITING

Bodelwyddan, United Kingdom
UK-Bristol-BRISTOLCENTRE
RECRUITING

Bristol, United Kingdom
UK-Cornwall-RCH
NOT_YET_RECRUITING

Truro, United Kingdom
UK-Coventry-UHCOVENTRYANDWARWICKSHIRE
RECRUITING

Coventry, United Kingdom
UK-Derby-ROYALDERBYHOSPITAL
NOT_YET_RECRUITING

Derby, United Kingdom
UK-Edinburgh-WGH
NOT_YET_RECRUITING

Edinburgh, United Kingdom
UK-Harrow-NORTHWICK
NOT_YET_RECRUITING

Harrow, United Kingdom
UK-Hull-CASTLEHILL
RECRUITING

Hull, United Kingdom
UK-Manchester-ROYALINFIRMARY
RECRUITING

Manchester, United Kingdom
UK-Portsmouth-QUEENALEXANDRA
RECRUITING

Cosham, United Kingdom
UK-Stoke on Trent-UHNM
NOT_YET_RECRUITING

Stoke-on-Trent, United Kingdom
UK-Swindon-GWH
NOT_YET_RECRUITING

Swindon, United Kingdom
US-Atlanta GA-EMORY
RECRUITING

Atlanta, Georgia, 30322, United States
US-Baltimore MD-UMGCCC
RECRUITING

Baltimore, Maryland, 21201, United States
US-Chapel Hill-UNCNORTHCAROLINA
RECRUITING

Chapel Hill, North Carolina, 27514, United States
US-Cincinnati OH-CINCY
RECRUITING

Cincinnati, Ohio, 45219, United States
US-Colombus OH-OSU
NOT_YET_RECRUITING

Columbus, Ohio, 43210, United States
US-Dallas TX-SOUTHWESTERN
NOT_YET_RECRUITING

Dallas, Texas, 75390, United States
US-Jacksonville FL-MAYOFL
NOT_YET_RECRUITING

Jacksonville, Florida, 32224, United States
US-Kansas City KS-KUMC
NOT_YET_RECRUITING

Fairway, Kansas, 66205, United States
US-Los Angeles CA-UCLA
NOT_YET_RECRUITING

Los Angeles, California, 90095, United States
US-New York-MSKCC
NOT_YET_RECRUITING

New York, New York, 10065, United States
US-Pittsburgh PA-PITT
NOT_YET_RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
US-Portland OR-OHSU
NOT_YET_RECRUITING

Portland, Oregon, 97239, United States
US-Providence RI-BROWN
NOT_YET_RECRUITING

Providence, Rhode Island, 02906, United States
US-Rochester MN-MAYOMN
NOT_YET_RECRUITING

Rochester, Minnesota, 55905, United States
US-San Francisco CA-UCSF
NOT_YET_RECRUITING

San Francisco, California, 94143, United States
US-Wheeling WV-WVU
RECRUITING

Wheeling, West Virginia, 26003, United States
University College Hospital
RECRUITING

London, United Kingdom
University Hospital of Wales
RECRUITING

Cardiff, United Kingdom
University Hospitals of Leicester NHS Trust
RECRUITING

Leicester, United Kingdom

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