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New hope for leukemia patients Who've run out of options

NCT ID NCT05304377

Recruiting now Disease control Sponsor: Enliven Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study tests a new drug called ELVN-001 in people with chronic myeloid leukemia (CML) whose cancer has not responded to or who cannot tolerate other treatments. The main goals are to check the drug's safety and find the best dose. About 250 adults with CML will take part.

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Conditions

The condition(s) this trial relates to.

chronic myelogenous leukemia, BCR-ABL1 positive Leukemia, Myelogenous, Chronic, BCR-ABL Positive Leukemia, Myeloid, Chronic-Phase

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC MYELOID LEUKEMIA CHRONIC PHASE CHRONIC MYELOID LEUKEMIA, BCR-ABL1 POSITIVE CML

Contacts and locations

Locations

  • Azienda Ospedaliero Universitaria Delle Marche

    RECRUITING

    Ancona, 60126, Italy

  • Beatson West of Scotland Cancer Centre, Gartnavel General Hospital

    RECRUITING

    Glasgow, G12 0YN, United Kingdom

  • CHRU de Lille - Hopital Calmette-Boulevard du Pr Leclercq CHRU Lille

    RECRUITING

    Lille, 59000, France

  • CHU Amiens Picardie Site Sud

    RECRUITING

    Amiens, 80054, France

  • CHU Liege

    RECRUITING

    Liège, 4000, Belgium

  • Centre Hospitalier Lyon Sud

    WITHDRAWN

    Pierre-Bénite, 69495, France

  • Centre Hospitalier Universitaire (CHU) De Limoges Hopital Dupuytren

    RECRUITING

    Limoges, 87000, France

  • Centre Leon Berard

    RECRUITING

    Lyon, 69008, France

  • Charite Campus Virchow

    RECRUITING

    Berlin, 13353, Germany

  • Chonbuk National University Hospital

    WITHDRAWN

    Jeonju, Jeollabuk-do, 54907, South Korea

  • Chonnam National University Hwasun Hospital

    WITHDRAWN

    Hwasun, 58128, South Korea

  • Complejo Hospitalario de Toledo - Hospital Virgen de la Salud

    TERMINATED

    Toledo, 45007, Spain

  • Hadassah Medical Center

    RECRUITING

    Jerusalem, 9112001, Israel

  • Hammersmith Hospital Imperial College Healthcare NHS Trust

    RECRUITING

    London, W12 0HS, United Kingdom

  • Hospital Del Mar

    RECRUITING

    Barcelona, 08003, Spain

  • Hospital Universitario La Paz

    RECRUITING

    Madrid, 28046, Spain

  • Hospital Universitario de Gran Canaria Dr. Negrin, Servicio Canario e Salud (SCS)

    WITHDRAWN

    Las Palmas de Gran Canaria, 35010, Spain

  • Institut Bergonie - Centre Regional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest

    RECRUITING

    Bordeaux, 33076, France

  • Instytut Hematologii I Transfuzjologii

    RECRUITING

    Warsaw, 02-776, Poland

  • Keimyung University Dongsan Hospital

    WITHDRAWN

    Daegu, 42601, South Korea

  • Klinikum der Goethe Universitat

    RECRUITING

    Frankfurt, 60596, Germany

  • MICS Centrum Medyczne Torun

    RECRUITING

    Torun, 87-100, Poland

  • Medizinische Universitatsklinik Mannheim der Universitat Heidelberg

    RECRUITING

    Mannheim, 68167, Germany

  • Memorial Sloan Kettering Cancer Center

    RECRUITING

    New York, New York, 10065, United States

  • Montefiore Medical Center

    RECRUITING

    The Bronx, New York, 10461, United States

  • Oregon Health & Science University-Knight Cardiovascular Institute

    RECRUITING

    Portland, Oregon, 97239, United States

  • Pecsi Tudomanyegyetem Klinikai Kozpont (University of Pecs, Clinical Centre)

    RECRUITING

    Pécs, 7624, Hungary

  • Rabin Medical Center

    RECRUITING

    Petah Tikva, 4941492, Israel

  • Radboud University Medical Center

    RECRUITING

    Nijmegen, 6525, Netherlands

  • Royal Adelaide Hospital

    RECRUITING

    Adelaide, SA 5000, Australia

  • Samsung Medical Center

    WITHDRAWN

    Seoul, 06351, South Korea

  • Semmelweis Egyetem, Belgyogyaszati es Onkologiai Klinika

    RECRUITING

    Budapest, 1083, Hungary

  • Szpital Specjalistycnzy im. Jedrzeja Sniadeckiego w Nowym Saczu

    RECRUITING

    Nowy Sącz, 33-300, Poland

  • The Christie NHS Foundation Trust

    RECRUITING

    Manchester, M20 4BX, United Kingdom

  • The Galilee Medical Center

    RECRUITING

    Nahariya, 2210001, Israel

  • The University of Texas MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

  • UZ Gent

    RECRUITING

    Ghent, 9000, Belgium

  • UZ Leuven

    RECRUITING

    Leuven, 3000, Belgium

  • Uijeongbu Eulji Medical Center

    RECRUITING

    Gyeonggi-do, 11749, South Korea

  • Uniklinik RWTH Aachen Medizinische

    RECRUITING

    Aachen, 52074, Germany

  • Universitaetsklinikum Des Saarlandes Und Medizinische Fakultaet Der Universitaet Des Saarlandes

    RECRUITING

    Homburg, 66421, Germany

  • Universitaetsklinikum Jena

    RECRUITING

    Jena, 07747, Germany

  • Universitaetsmedizin Rostock

    RECRUITING

    Rostock, 18057, Germany

  • Universitat de Valencia - Hospital Universitari i Politecnic La Fe de Valencia (Hospital La Fe Bulevar Sur)

    RECRUITING

    Valencia, 46026, Spain

  • University Health Network (UHN) - Princess Margaret Cancer Centre

    RECRUITING

    Toronto, Ontario, M5G 2M9, Canada

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