New drug aims to reverse bone marrow scarring in rare blood cancer
NCT ID NCT07394153
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This phase 2 trial tests the drug pacritinib in 30 people with myelofibrosis, a rare bone marrow cancer, who also have low platelet counts. The goal is to see if pacritinib can reduce scarring (fibrosis) in the bone marrow and improve symptoms. Participants take pacritinib pills twice daily for up to two years, with regular check-ups and scans.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Pacritinib
What this could lead to
If successful, this could show that pacritinib reduces bone marrow scarring and improves blood cell counts in myelofibrosis patients with low platelets.
What could go wrong
This is a small, early-phase study with only 30 participants and no comparison group. The drug may cause side effects or fail to improve fibrosis.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Contact
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Locations
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Fundación Jimenez Díaz
RECRUITINGMadrid, Madrid, 28040, Spain
Contact
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Hospital Clinic de Barcelona
RECRUITINGBarcelona, Barcelona, 08036, Spain
Contact
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Hospital Clínico Universitario Valencia
NOT_YET_RECRUITINGValencia, Valencia, 46010, Spain
Contact
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Hospital General Universitario Gregorio Marañon
RECRUITINGMadrid, Madrid, 28007, Spain
Contact
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Hospital General Universitario Morales Meseguer
RECRUITINGMurcia, Murcia, 30008, Spain
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Hospital General Universitario de Valencia
RECRUITINGValencia, Valencia, 46014, Spain
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Hospital Universitario 12 de Octubre
RECRUITINGMadrid, Madrid, 28041, Spain
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Hospital Universitario Doctor Peset
NOT_YET_RECRUITINGValencia, Valencia, 46017, Spain
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Hospital Universitario Ramon y Cajal
RECRUITINGMadrid, Madrid, 28034, Spain
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Hospital Universitario Vall d´Hebron
RECRUITINGBarcelona, Barcelona, 08035, Spain
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Hospital Universitario de Jerez
NOT_YET_RECRUITINGJerez de la Frontera, Cádiz, 11407, Spain
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Hospital Universitario de Salamanca
NOT_YET_RECRUITINGSalamanca, Salamanca, 37007, Spain
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Hospital del Mar Barcelona
RECRUITINGBarcelona, Barcelona, 08003, Spain
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