MYELOFIBROSIS (MF)
Clinical trials for MYELOFIBROSIS (MF) explained in plain language.
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New hope for myelofibrosis: experimental combo targets Drug-Resistant patients
Disease control Recruiting nowThis early-stage trial is testing whether adding roginolisib to the standard drug ruxolitinib is safe and tolerable for adults with myelofibrosis whose disease no longer responds to JAK inhibitors. The study will enroll 26 participants and monitor side effects, heart changes, and…
Matched conditions: MYELOFIBROSIS (MF)
Phase: PHASE1, PHASE2 • Sponsor: iOnctura • Aim: Disease control
Last updated Jun 27, 2026 14:01 UTC
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New drug aims to reverse bone marrow scarring in rare blood cancer
Disease control Recruiting nowThis phase 2 trial tests the drug pacritinib in 30 people with myelofibrosis, a rare bone marrow cancer, who also have low platelet counts. The goal is to see if pacritinib can reduce scarring (fibrosis) in the bone marrow and improve symptoms. Participants take pacritinib pills …
Matched conditions: MYELOFIBROSIS (MF)
Phase: PHASE2 • Sponsor: Grupo Español de Enfermedades Mieloproliferativas Crónicas PH Negativas • Aim: Disease control
Last updated Jun 27, 2026 14:01 UTC
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New hope for rare blood cancers: first human trial of PRT12396 begins
Disease control Recruiting nowThis early-stage study tests a new drug, PRT12396, in about 100 people with polycythemia vera or myelofibrosis—rare blood cancers. The main goals are to find a safe dose and check for side effects. Researchers will also look for signs that the drug controls the disease, but this …
Matched conditions: MYELOFIBROSIS (MF)
Phase: PHASE1 • Sponsor: Prelude Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 13:04 UTC
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New combo therapy hopes to shrink spleens and ease symptoms in Tough-to-Treat myelofibrosis
Disease control Recruiting nowThis early-phase trial tests a combination of two drugs, tagraxofusp and pacritinib, in about 20 adults with myelofibrosis (a bone marrow disorder) who have already tried standard JAK inhibitors or cannot use them. The main goals are to see if the combo can shrink an enlarged spl…
Matched conditions: MYELOFIBROSIS (MF)
Phase: EARLY_PHASE1 • Sponsor: University of Kansas Medical Center • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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New drug duo aims to tame rare bone marrow cancers
Disease control Recruiting nowThis study tests two drugs—axatilimab and ruxolitinib—together in people with myelofibrosis or chronic myelomonocytic leukemia. The goal is to find a safe dose and see if the combination helps control the disease. About 66 adults who have tried other treatments or are new to ther…
Matched conditions: MYELOFIBROSIS (MF)
Phase: PHASE1, PHASE2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 08:08 UTC
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Can a $10 arthritis pill tame rare blood cancers?
Disease control Recruiting nowThis study tests low-dose methotrexate, a common arthritis drug, in 54 people with three rare blood cancers: polycythemia vera, essential thrombocythemia, and myelofibrosis. Researchers want to see if it can shrink spleens, improve symptoms, and lower blood counts safely. If succ…
Matched conditions: MYELOFIBROSIS (MF)
Phase: PHASE2 • Sponsor: Icahn School of Medicine at Mount Sinai • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC
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Could a simple blood test and PET scan replace painful bone marrow biopsies for myelofibrosis patients?
Diagnosis Recruiting nowThis study aims to develop a non-invasive method to detect and track fibrosis (scarring) in myelofibrosis, a serious blood disorder. Currently, doctors must perform a bone marrow biopsy to check fibrosis. The researchers will test whether a blood test and a special PET scan can i…
Matched conditions: MYELOFIBROSIS (MF)
Phase: NA • Sponsor: Azienda Ospedaliero-Universitaria di Parma • Aim: Diagnosis
Last updated Jun 27, 2026 09:06 UTC
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Massive new study aims to unlock secrets of rare blood cancers
Knowledge-focused Recruiting nowThis long-term observational study is enrolling 5,000 adults with myeloproliferative neoplasms (MPNs)—rare blood cancers like polycythemia vera and myelofibrosis. Researchers will collect health records, patient surveys, and insurance data over at least five years to track sympto…
Matched conditions: MYELOFIBROSIS (MF)
Sponsor: MPN Research Foundation • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:13 UTC