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New hope for rare blood cancers: first human trial of PRT12396 begins

NCT ID NCT07469891

Recruiting now Disease control Sponsor: Prelude Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 1 time

Summary

This early-stage study tests a new drug, PRT12396, in about 100 people with polycythemia vera or myelofibrosis—rare blood cancers. The main goals are to find a safe dose and check for side effects. Researchers will also look for signs that the drug controls the disease, but this is not a cure and long-term management is expected.

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Conditions

The condition(s) this trial relates to.

acquired polycythemia vera myelofibrosis Myeloproliferative Disorders myeloproliferative neoplasm primary myelofibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MYELOFIBROSIS，MF MYELOPROLIFERATIVE NEOPLASMS (MPNS) POLYCYTHEMIA VERA (PV) POST POLYCYTHEMIA VERA MYELOFIBROSIS POST-ESSENTIAL THROMBOCYTHEMIA MYELOFIBROSIS PRIMARY MYELOFIBROSIS (PMF)

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • BRCR Global - Coral Springs

    RECRUITING

    Coral Springs, Florida, 33065, United States

  • Colorado Blood Cancer Institute

    RECRUITING

    Denver, Colorado, 80218, United States

  • Moffitt Cancer Center

    RECRUITING

    Tampa, Florida, 33612, United States

  • START Midwest, LLC

    RECRUITING

    Grand Rapids, Michigan, 49546, United States

  • Tennessee Oncology, PLLC - Investigational Drug Services

    RECRUITING

    Nashville, Tennessee, 37203, United States

  • The University of Texas, MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

  • Thomas Jefferson University, Sidney Kimmel Cancer Center, Clinical Trials Office

    RECRUITING

    Philadelphia, Pennsylvania, 19107, United States

  • Tristar BMT

    RECRUITING

    Nashville, Tennessee, 37203, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.