New hope for young AML patients: targeted drug combo tested in phase 2 trial

NCT ID NCT06917911

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 15 times

Summary

This study tests two different drug combinations for younger adults with a specific type of acute myeloid leukemia (CBF-AML). One group gets standard chemotherapy plus a targeted antibody, while the other gets the same chemotherapy plus a newer targeted pill. The goal is to see which combination works better at clearing the cancer with fewer side effects. About 162 people will take part.

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Conditions

The condition(s) this trial relates to.

core binding factor acute myeloid leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORE BINDING FACTOR ACUTE MYELOID LEUKEMIA

Contacts and locations

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Locations

Baptist Cancer Center-Grenada
RECRUITING

Grenada, Mississippi, 38901, United States

Contact Email: •••••@•••••
Baptist Memorial Hospital and Cancer Center-Collierville
RECRUITING

Collierville, Tennessee, 38017, United States

Contact Email: •••••@•••••
Baptist Memorial Hospital and Cancer Center-Desoto
RECRUITING

Southhaven, Mississippi, 38671, United States

Contact Email: •••••@•••••
Baptist Memorial Hospital and Cancer Center-Golden Triangle
RECRUITING

Columbus, Mississippi, 39705, United States

Contact Email: •••••@•••••
Baptist Memorial Hospital and Cancer Center-Memphis
RECRUITING

Memphis, Tennessee, 38120, United States

Contact Email: •••••@•••••
Baptist Memorial Hospital and Cancer Center-Oxford
RECRUITING

Oxford, Mississippi, 38655, United States

Contact Email: •••••@•••••
Baptist Memorial Hospital and Cancer Center-Union County
RECRUITING

New Albany, Mississippi, 38652, United States

Contact Email: •••••@•••••
Benefis Sletten Cancer Institute
RECRUITING

Great Falls, Montana, 59405, United States

Contact Email: •••••@•••••
Bozeman Health Deaconess Hospital
RECRUITING

Bozeman, Montana, 59715, United States

Contact Email: •••••@•••••
Community Medical Center
RECRUITING

Missoula, Montana, 59804, United States

Contact Email: •••••@•••••
Gundersen Lutheran Medical Center
RECRUITING

La Crosse, Wisconsin, 54601, United States

Contact Email: •••••@•••••
Kootenai Clinic Cancer Services - Post Falls
RECRUITING

Post Falls, Idaho, 83854, United States

Contact Email: •••••@•••••
Kootenai Clinic Cancer Services - Sandpoint
RECRUITING

Sandpoint, Idaho, 83864, United States

Contact Email: •••••@•••••
Kootenai Health - Coeur d'Alene
RECRUITING

Coeur d'Alene, Idaho, 83814, United States

Contact Email: •••••@•••••
Memorial Hospital West
RECRUITING

Pembroke Pines, Florida, 33028, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States

Contact Email: •••••@•••••
Prisma Health Cancer Institute - Butternut
RECRUITING

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Easley
RECRUITING

Easley, South Carolina, 29640, United States
Prisma Health Cancer Institute - Eastside
RECRUITING

Greenville, South Carolina, 29615, United States
Prisma Health Cancer Institute - Faris
RECRUITING

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Greer
RECRUITING

Greer, South Carolina, 29650, United States
Prisma Health Cancer Institute - Seneca
RECRUITING

Seneca, South Carolina, 29672, United States
Prisma Health Cancer Institute - Spartanburg
RECRUITING

Boiling Springs, South Carolina, 29316, United States
The James Graham Brown Cancer Center at University of Louisville
RECRUITING

Louisville, Kentucky, 40202, United States
Trinity Health IHA Medical Group Hematology Oncology - Brighton
RECRUITING

Brighton, Michigan, 48114, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton
RECRUITING

Canton, Michigan, 48188, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
RECRUITING

Chelsea, Michigan, 48118, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
RECRUITING

Ypsilanti, Michigan, 48197, United States
Trinity Health Saint Joseph Mercy Oakland Hospital
RECRUITING

Pontiac, Michigan, 48341, United States
Trinity Health Saint Mary Mercy Livonia Hospital
RECRUITING

Livonia, Michigan, 48154, United States
Tufts Medical Center
RECRUITING

Boston, Massachusetts, 02111, United States
University of Kansas Cancer Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Kansas Clinical Research Center
RECRUITING

Fairway, Kansas, 66205, United States
University of Kansas Hospital-Indian Creek Campus
RECRUITING

Overland Park, Kansas, 66211, United States
University of Kansas Hospital-Westwood Cancer Center
RECRUITING

Westwood, Kansas, 66205, United States
University of Rochester
RECRUITING

Rochester, New York, 14642, United States
UofL Health Medical Center Northeast
RECRUITING

Louisville, Kentucky, 40245, United States

Contact Email: •••••@•••••

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