Immune cells harvested from tumors could fight advanced cancers
NCT ID NCT05607095
First seen Jun 26, 2026 · Last updated Jul 14, 2026 · Updated 3 times
Summary
This early-stage trial tests a personalized cell therapy called lifileucel for people with advanced uveal melanoma (a rare eye cancer) or certain sarcomas (connective tissue cancers). The treatment involves removing immune cells from the patient's tumor, growing them in a lab, and infusing them back after a short course of chemotherapy. The main goal is to check safety in 30 participants.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Lifileucel (LN-144/LN-145) - a personalized cell therapy using the patient's own immune cells (tumor-infiltrating lymphocytes)
- What this could lead to
- If successful, this could point toward a new treatment option for advanced uveal melanoma and certain sarcomas that have not responded to standard therapies.
- What could go wrong
- This is a very early (Phase 1) trial with only 30 participants, so the main goal is safety, not effectiveness. The therapy involves intensive chemotherapy and high-dose IL-2, which can cause serious side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
RECRUITINGNew York, New York, 10065, United States
-
Memorial Sloan Kettering Westchester
RECRUITINGHarrison, New York, 10604, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a new drug tame advanced solid tumors?