New hope for tough leukemia? early trial of debio 1562M begins

NCT ID NCT06969430

Recruiting now Disease control Sponsor: Debiopharm International SA Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 13, 2026 · Updated 4 times

Summary

This early-phase trial is testing a new drug called Debio 1562M in about 134 people with acute myeloid leukemia (AML) that has come back or not responded to other treatments. The study first checks safety and finds the right dose, then looks at whether the drug can shrink the cancer. It's an open-label trial, meaning everyone knows they are getting the experimental drug.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Debio 1562M (a drug given by IV infusion)
What this could lead to: If it works, this could point toward a new treatment option for people with hard-to-treat acute myeloid leukemia.
What could go wrong: This is a very early, first-in-human trial, so safety and effectiveness are not yet known. It may not work or could cause serious side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia myelodysplastic syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

City of Hope Comprehensive Cancer Center
RECRUITING

Duarte, California, 91010, United States
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Moffitt Cancer Center and Research Institute Hospital
RECRUITING

Tampa, Florida, 33612-9416, United States
Roswell Park Comprehensive Cancer Center
RECRUITING

Buffalo, New York, 14203, United States
START Midwest
RECRUITING

Grand Rapids, Michigan, 49546, United States
The Ohio Sate University
RECRUITING

Columbus, Ohio, 43210, United States
University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States

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