Could a common osteoporosis drug stop bone tumors from coming back?
NCT ID NCT03295981
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial tests whether adding zoledronic acid (a bisphosphonate) to bone cement during surgery can lower the chance of a giant cell tumor of bone returning. About 120 people with primary tumors in their arms or legs will be randomly assigned to receive either standard surgery or surgery with the drug. The main goal is to see if the drug reduces local recurrence rates.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
zoledronic acid (bisphosphonate) added to bone cement
What this could lead to
If it works, this could offer a simple way to lower the chance of a giant cell tumor coming back after surgery, reducing the need for repeat operations.
What could go wrong
This is a relatively small trial (120 people) and results may not apply to all patients. There is also a risk of surgical site infection or other complications from the added drug.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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All India Institute of Medical Science
RECRUITINGNew Delhi, 110029, India
Contact
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Allegheny-Singer Research Institute
RECRUITINGPittsburgh, Pennsylvania, 15212, United States
Contact
Contact Email: •••••@•••••
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Beth Israel Deaconess Medical Center
RECRUITINGBoston, Massachusetts, 02215, United States
Contact Email: •••••@•••••
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Boston Children's Hospital
RECRUITINGBoston, Massachusetts, 02115, United States
Contact
Contact Email: •••••@•••••
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Cleveland Clinic
RECRUITINGCleveland, Ohio, 44195, United States
Contact Email: •••••@•••••
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Indiana University
RECRUITINGIndianapolis, Indiana, 46202, United States
Contact Email: •••••@•••••
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Contact
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Johns Hopkins University Hospital
RECRUITINGBaltimore, Maryland, 21287, United States
Contact
Contact Email: •••••@•••••
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
Contact Email: •••••@•••••
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McGill University Health Centre
COMPLETEDMontreal, Quebec, H3G 1A4, Canada
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Saint Louis University
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California - Los Angeles
RECRUITINGLos Angeles, California, 90404, United States
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Contact
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University of Iowa
RECRUITINGIowa City, Iowa, 52242, United States
Contact Email: •••••@•••••
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University of Kansas
COMPLETEDOverland Park, Kansas, 66211, United States
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University of Oklahoma
RECRUITINGOklahoma City, Oklahoma, 73104, United States
Contact
Contact Email: •••••@•••••
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University of Washington
COMPLETEDSeattle, Washington, 98195, United States
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Wake Forest University
COMPLETEDWinston-Salem, North Carolina, 27157, United States