Could a targeted pill boost chemo for tough blood cancer?

NCT ID NCT04628026

Recruiting now Disease control Sponsor: University of Ulm Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 07, 2026 · Updated 7 times

Summary

This Phase 3 trial tests whether adding the drug venetoclax to standard chemotherapy helps adults with newly diagnosed acute myeloid leukemia (AML) or a related high-risk condition. About 650 participants aged 18 to 75 will receive either venetoclax or a placebo alongside chemo. The study measures how long people stay free of cancer events and overall survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Venetoclax
What this could lead to: If successful, adding venetoclax to standard chemotherapy could improve remission rates and extend survival for people with newly diagnosed acute myeloid leukemia.
What could go wrong: This is a large Phase 3 trial, but venetoclax may cause serious side effects like low blood counts and infections. It is not a cure, and some patients may not benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia myelodysplastic syndrome with excess blasts-2

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA

Contacts and locations

Locations

Albert Schweitzer Ziekenhuis
RECRUITING

Dordrecht, Netherlands
Algemeen Ziekenhuis Delta
RECRUITING

Roeselare, Belgium
Amphia Hospital
RECRUITING

Breda, Netherlands
Amsterdam UMC Stichting
RECRUITING

Amsterdam, Netherlands
Asklepios Klinik Altona
RECRUITING

Hamburg, Germany
Asklepios Klinik St Georg
RECRUITING

Hamburg, Germany
Az St-Jan Brugge-Oostende A.V.
NOT_YET_RECRUITING

Bruges, Belgium
Barmherzige Brueder Trier gGmbH
NOT_YET_RECRUITING

Trier, Germany
CHU UCL NAMUR - Mont Godinne
RECRUITING

Yvoir, Belgium
Charité Berlin - Campus Benjamin Franklin
RECRUITING

Berlin, 12200, Germany
Charité Berlin - Campus Mitte
RECRUITING

Berlin, 10117, Germany
Charité Berlin - Campus Virchow Klinikum
RECRUITING

Berlin, Germany
Diakonie Klinikum Stuttgart
RECRUITING

Stuttgart, 70176, Germany
Erasmus MC - Daniel
RECRUITING

Rotterdam, Netherlands
Gemeinnuetzige Salzburger Landeskliniken Betriebsgesellschaft mbH
NOT_YET_RECRUITING

Salzburg, Austria
Gesundheit Nord gGmbH Klinikverbund Bremen
RECRUITING

Bremen, Germany
HELIOS Klinikum Bad Saarow GmbH
RECRUITING

Bad Saarow, Germany
Hagaziekenhuis, locatie Leyweg
RECRUITING

The Hague, Netherlands
Hanusch Krankenhaus Der Wiener Gebietskrankenkasse
RECRUITING

Vienna, Austria
Haukeland University Hospital
NOT_YET_RECRUITING

Bergen, Norway
Helios Universitaetsklinikum Wuppertal
RECRUITING

Wuppertal, Germany
Helsinki University Central Hospital Meilahden Kolmiosairaala
NOT_YET_RECRUITING

Helsinki, Finland
Isala Klinieken Stichting
RECRUITING

Zwolle, Netherlands
Jeroen Bosch ziekenhuis
RECRUITING

's-Hertogenbosch, Netherlands
Justus-Liebig-Universitaet Giessen
RECRUITING

Giessen, Germany
KRH Klinikum Siloah
RECRUITING

Hanover, Germany
Katholieke Universiteit te Leuven
NOT_YET_RECRUITING

Leuven, Belgium
Kepler Universitaetsklinikum GmbH
NOT_YET_RECRUITING

Linz, Austria
Klinikum Aschaffenburg-Alzenau gGmbH
RECRUITING

Aschaffenburg, Germany
Klinikum Darmstadt GmbH
NOT_YET_RECRUITING

Darmstadt, Germany
Klinikum Frankfurt Hoechst GmbH
RECRUITING

Frankfurt, Germany
Klinikum Hochsauerland GmbH
RECRUITING

Meschede, Germany
Klinikum Mutterhaus der Borromaerinnen
RECRUITING

Trier, Germany
Klinikum Oldenburg AöR
RECRUITING

Oldenburg, Germany
Klinikum Traunstein
RECRUITING

Traunstein, Germany
Klinikum der Stadt Ludwigshafen am Rhein gGmbH
RECRUITING

Ludwigshafen, Germany
Klinikum rechts der Isar der TU Muenchen AöR
RECRUITING

München, Germany
Knappschaftskrankenhaus Bochum-Langendreer
RECRUITING

Bochum, 44892, Germany
Landeskrankenhaus (LKH) Rankweil, Interne E am Landeskrankenhaus Rankweil
NOT_YET_RECRUITING

Rankweil, Austria
Leids Universitair Medisch Centrum (LUMC)
RECRUITING

Leiden, Netherlands
Maastricht University Medical Center+ (MUMC+)
NOT_YET_RECRUITING

Maastricht, Netherlands
Marien Hospital Duesseldorf GmbH
WITHDRAWN

Düsseldorf, Germany
Marien Hospital Herne
RECRUITING

Herne, Germany
Maxima Medisch Centrum
RECRUITING

Eindhoven, Netherlands
Meander Medisch Centrum
RECRUITING

Amersfoort, Netherlands
Medisch Centrum Leeuwarden B.V.
RECRUITING

Leeuwarden, Netherlands
Medisch Spectrum Twente
RECRUITING

Enschede, Netherlands
Medizinische Hochschule Hannover
RECRUITING

Hanover, 30625, Germany
Muhlenkreiskliniken AöR
RECRUITING

Minden, Germany
North Estonia Medical Centre Foundation
RECRUITING

Tallinn, Estonia
OLVG
RECRUITING

Amsterdam, Netherlands
Ordensklinikum Linz GmbH
NOT_YET_RECRUITING

Linz, Austria
Ortenauklinikum
RECRUITING

Offenburg, Germany
Otto Von Guericke Universitaet Magdeburg
RECRUITING

Magdeburg, Germany
Radboudumc
RECRUITING

Nijmegen, Netherlands
Reinier de Graaf Gasthuis
RECRUITING

Delft, Netherlands
Rijnstate Ziekenhuis Stichting
RECRUITING

Arnhem, Netherlands
SLK-Kliniken Heilbronn GmbH
RECRUITING

Heilbronn, Germany
Schwarzwald-Baar Klinikum Villingen-Schwenningen GmbH
RECRUITING

Villingen-Schwenningen, Germany
Sint Antonius Ziekenhuis Stichting
RECRUITING

Nieuwegein, Netherlands
St. Johannes Hospital Dortmund
RECRUITING

Dortmund, Germany
St. Olavs Hospital
RECRUITING

Trondheim, Norway
Staedtisches Klinikum Braunschweig
RECRUITING

Braunschweig, 38114, Germany
Staedtisches Klinikum Karlsruhe gGmbH
NOT_YET_RECRUITING

Karlsruhe, Germany
Stavanger Univ. Hosp.-Rogaland Hosp.
NOT_YET_RECRUITING

Oslo, Norway
Städtisches Klinikum Karlsruhe
RECRUITING

Karlsruhe, 76133, Germany
Tampere University Hospital
NOT_YET_RECRUITING

Tampere, Finland
Tartu University Hospital
RECRUITING

Tartu, Estonia
Tirol Kliniken GmbH
NOT_YET_RECRUITING

Innsbruck, Austria
UMCG
RECRUITING

Groningen, Netherlands
UMCU
RECRUITING

Utrecht, Netherlands
UNIVERSITÄTSKLINIKUM Schleswig-Holstein
RECRUITING

Lübeck, Germany
Uniklinikum Bonn
RECRUITING

Bonn, 53127, Germany
Uniklinikum Tübingen
RECRUITING

Tübingen, 72076, Germany
Univeritätsklinikum
RECRUITING

Halle, Germany
Universitaetsklinikum
RECRUITING

Rostock, Germany
Universitaetsklinikum Regensburg AöR
NOT_YET_RECRUITING

Regensburg, Germany
Universitaetsklinikum des Saarlandes AöR
RECRUITING

Homburg, Germany
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR
RECRUITING

Mainz, Germany
Universitair Ziekenhuis Brussel
RECRUITING

Brussels, Belgium
University Hospital Ulm
RECRUITING

Ulm, 89081, Germany
University Hospital of North Norway
NOT_YET_RECRUITING

Tromsø, Norway
Universitätsklinikum Hamburg-Eppendorf
RECRUITING

Hamburg, 20246, Germany
Universitätsmedizin Greifswald
RECRUITING

Greifswald, Germany
Vilnius University Hospital Santaros Klinik
NOT_YET_RECRUITING

Vilnius, Lithuania
Vivantes Neukölln
NOT_YET_RECRUITING

Berlin, Germany
Vivantes Spandau
WITHDRAWN

Berlin, Germany
Vivantes am Urban
NOT_YET_RECRUITING

Berlin, Germany
Wespfalz-Klinikum
RECRUITING

Kaiserslautern, Germany
Wilhelm-Anton-Hospital Goch
RECRUITING

Goch, Germany
Ziekenhuis Aan De Stroom
NOT_YET_RECRUITING

Antwerp, Belgium

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