New combo therapy aims to boost remission in IDH2-Mutated AML

NCT ID NCT06672146

Recruiting now Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 11, 2026 · Updated 7 times

Summary

This phase II trial tests whether adding enasidenib to standard ASTX727 and venetoclax improves remission rates in older adults (or younger unfit patients) with newly diagnosed IDH2-mutated acute myeloid leukemia (AML). About 93 participants will be randomly assigned to receive either the two-drug or three-drug combination. The main goal is to see if the triple therapy leads to deeper remissions with no detectable cancer cells.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ASTX727 (decitabine and cedazuridine), venetoclax, and enasidenib
What this could lead to: If successful, this could lead to a more effective treatment option for older adults with IDH2-mutated AML, potentially increasing the chance of achieving deep remission.
What could go wrong: This is a phase II trial with only 93 participants, so results are preliminary. Adding enasidenib may increase side effects without improving outcomes, and the study uses a lenient statistical threshold.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA

Contacts and locations

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Locations

Abbott-Northwestern Hospital
RECRUITING

Minneapolis, Minnesota, 55407, United States
Allegiance Health
RECRUITING

Jackson, Michigan, 49201, United States

Contact Email: •••••@•••••
Alta Bates Summit Medical Center-Herrick Campus
ACTIVE_NOT_RECRUITING

Berkeley, California, 94704, United States
Augusta University Medical Center
RECRUITING

Augusta, Georgia, 30912, United States
Banner University Medical Center - Tucson
RECRUITING

Tucson, Arizona, 85719, United States
Benefis Sletten Cancer Institute
RECRUITING

Great Falls, Montana, 59405, United States

Contact Email: •••••@•••••
Billings Clinic Cancer Center
RECRUITING

Billings, Montana, 59101, United States

Contact Email: •••••@•••••
Bozeman Health Deaconess Hospital
RECRUITING

Bozeman, Montana, 59715, United States

Contact Email: •••••@•••••
Cancer Hematology Centers - Flint
RECRUITING

Flint, Michigan, 48503, United States
Carolinas Medical Center/Levine Cancer Institute
RECRUITING

Charlotte, North Carolina, 28203, United States
Centro Comprensivo de Cancer de UPR
RECRUITING

San Juan, 00927, Puerto Rico
Community Hospital of Anaconda
RECRUITING

Anaconda, Montana, 59711, United States

Contact Email: •••••@•••••
Community Medical Center
RECRUITING

Missoula, Montana, 59804, United States

Contact Email: •••••@•••••
Community Medical Center
RECRUITING

Toms River, New Jersey, 08755, United States
Cooperman Barnabas Medical Center
RECRUITING

Livingston, New Jersey, 07039, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27710, United States
Duluth Clinic Ashland
RECRUITING

Ashland, Wisconsin, 54806, United States

Contact Email: •••••@•••••
East Carolina University
RECRUITING

Greenville, North Carolina, 27834, United States
Essentia Health - Deer River Clinic
RECRUITING

Deer River, Minnesota, 56636, United States

Contact Email: •••••@•••••
Essentia Health Cancer Center
RECRUITING

Duluth, Minnesota, 55805, United States

Contact Email: •••••@•••••
Essentia Health Hibbing Clinic
RECRUITING

Hibbing, Minnesota, 55746, United States
Essentia Health Sandstone
RECRUITING

Sandstone, Minnesota, 55072, United States

Contact Email: •••••@•••••
Essentia Health Virginia Clinic
RECRUITING

Virginia, Minnesota, 55792, United States

Contact Email: •••••@•••••
Fairview Southdale Hospital
RECRUITING

Edina, Minnesota, 55435, United States
Geisinger Medical Center
RECRUITING

Danville, Pennsylvania, 17822, United States

Contact Email: •••••@•••••
Geisinger Wyoming Valley/Henry Cancer Center
RECRUITING

Wilkes-Barre, Pennsylvania, 18711, United States

Contact Email: •••••@•••••
Genesee Hematology Oncology PC
SUSPENDED

Flint, Michigan, 48503, United States
Genesys Hurley Cancer Institute
RECRUITING

Flint, Michigan, 48503, United States
Gundersen Lutheran Medical Center
RECRUITING

La Crosse, Wisconsin, 54601, United States

Contact Email: •••••@•••••
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States

Contact Email: •••••@•••••
Henry Ford Macomb Hospital-Clinton Township
RECRUITING

Clinton Township, Michigan, 48038, United States

Contact Email: •••••@•••••
Henry Ford Medical Center-Columbus
RECRUITING

Novi, Michigan, 48377, United States

Contact Email: •••••@•••••
Henry Ford West Bloomfield Hospital
RECRUITING

West Bloomfield, Michigan, 48322, United States

Contact Email: •••••@•••••
Huntsman Cancer Institute/University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States

Contact Email: •••••@•••••
Kootenai Clinic Cancer Services - Post Falls
RECRUITING

Post Falls, Idaho, 83854, United States

Contact Email: •••••@•••••
Kootenai Clinic Cancer Services - Sandpoint
RECRUITING

Sandpoint, Idaho, 83864, United States

Contact Email: •••••@•••••
Kootenai Health - Coeur d'Alene
RECRUITING

Coeur d'Alene, Idaho, 83814, United States

Contact Email: •••••@•••••
Logan Health Medical Center
RECRUITING

Kalispell, Montana, 59901, United States

Contact Email: •••••@•••••
Loyola University Medical Center
RECRUITING

Maywood, Illinois, 60153, United States
MaineHealth Cancer Care and IV Therapy - Brunswick
RECRUITING

Brunswick, Maine, 04011, United States

Contact Email: •••••@•••••
MaineHealth Cancer Care and IV Therapy - South Portland
RECRUITING

South Portland, Maine, 04106, United States

Contact Email: •••••@•••••
MaineHealth Maine Medical Center - Portland
RECRUITING

Portland, Maine, 04102, United States

Contact Email: •••••@•••••
MaineHealth Maine Medical Center- Scarborough
RECRUITING

Scarborough, Maine, 04074, United States

Contact Email: •••••@•••••
Marshfield Medical Center - Weston
RECRUITING

Weston, Wisconsin, 54476, United States

Contact Email: •••••@•••••
Marshfield Medical Center-River Region at Stevens Point
RECRUITING

Stevens Point, Wisconsin, 54482, United States

Contact Email: •••••@•••••
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Memorial Hospital West
RECRUITING

Pembroke Pines, Florida, 33028, United States
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
RECRUITING

Hollywood, Florida, 33021, United States
Memorial Sloan Kettering Basking Ridge
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Commack
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester
RECRUITING

Harrison, New York, 10604, United States
Mercy Hospital
RECRUITING

Coon Rapids, Minnesota, 55433, United States
Miami Cancer Institute
RECRUITING

Miami, Florida, 33176, United States
Mid Coast Hospital
RECRUITING

Brunswick, Maine, 04011, United States
Mills Health Center
ACTIVE_NOT_RECRUITING

San Mateo, California, 94401, United States
Monmouth Medical Center
RECRUITING

Long Branch, New Jersey, 07740, United States
NorthShore University HealthSystem-Evanston Hospital
RECRUITING

Evanston, Illinois, 60201, United States
NorthShore University HealthSystem-Glenbrook Hospital
RECRUITING

Glenview, Illinois, 60026, United States
NorthShore University HealthSystem-Highland Park Hospital
RECRUITING

Highland Park, Illinois, 60035, United States
Northwestern Medicine Cancer Center Delnor
RECRUITING

Geneva, Illinois, 60134, United States
Northwestern Medicine Cancer Center Kishwaukee
RECRUITING

DeKalb, Illinois, 60115, United States
Northwestern Medicine Cancer Center Warrenville
RECRUITING

Warrenville, Illinois, 60555, United States
Northwestern Medicine Glenview Outpatient Center
RECRUITING

Glenview, Illinois, 60026, United States
Northwestern Medicine Grayslake Outpatient Center
RECRUITING

Grayslake, Illinois, 60030, United States
Northwestern Medicine Lake Forest Hospital
RECRUITING

Lake Forest, Illinois, 60045, United States

Contact Email: •••••@•••••
Northwestern Medicine Orland Park
RECRUITING

Orland Park, Illinois, 60462, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States

Contact Email: •••••@•••••
OSF Saint Francis Hospital and Medical Group
RECRUITING

Escanaba, Michigan, 49829, United States
Oregon Health and Science University
SUSPENDED

Portland, Oregon, 97239, United States
Our Lady of The Lake
RECRUITING

Baton Rouge, Louisiana, 70808, United States
Our Lady of the Lake Physician Group
RECRUITING

Baton Rouge, Louisiana, 70808, United States

Contact Email: •••••@•••••
Park Nicollet Clinic - Saint Louis Park
RECRUITING

Saint Louis Park, Minnesota, 55416, United States
Prisma Health Cancer Institute - Butternut
RECRUITING

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Easley
RECRUITING

Easley, South Carolina, 29640, United States
Prisma Health Cancer Institute - Eastside
RECRUITING

Greenville, South Carolina, 29615, United States
Prisma Health Cancer Institute - Faris
RECRUITING

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Greer
RECRUITING

Greer, South Carolina, 29650, United States
Prisma Health Cancer Institute - Seneca
RECRUITING

Seneca, South Carolina, 29672, United States
Prisma Health Cancer Institute - Spartanburg
RECRUITING

Boiling Springs, South Carolina, 29316, United States
Regions Hospital
RECRUITING

Saint Paul, Minnesota, 55101, United States
Rhode Island Hospital
RECRUITING

Providence, Rhode Island, 02903, United States
Roswell Park Cancer Institute
RECRUITING

Buffalo, New York, 14263, United States
Rutgers Cancer Institute of New Jersey
RECRUITING

New Brunswick, New Jersey, 08903, United States
Saint Alphonsus Cancer Care Center-Nampa
RECRUITING

Nampa, Idaho, 83687, United States

Contact Email: •••••@•••••
Saint Luke's Cancer Institute - Boise
RECRUITING

Boise, Idaho, 83712, United States
Saint Luke's Cancer Institute - Fruitland
RECRUITING

Fruitland, Idaho, 83619, United States
Saint Luke's Cancer Institute - Meridian
RECRUITING

Meridian, Idaho, 83642, United States
Saint Luke's Cancer Institute - Nampa
RECRUITING

Nampa, Idaho, 83687, United States
Saint Vincent Hospital Cancer Center Green Bay
RECRUITING

Green Bay, Wisconsin, 54301, United States
Saint Vincent Hospital Cancer Center at Oconto Falls
RECRUITING

Oconto Falls, Wisconsin, 54154, United States
Saint Vincent Hospital Cancer Center at Saint Mary's
RECRUITING

Green Bay, Wisconsin, 54303, United States
Saint Vincent Hospital Cancer Center at Sheboygan
RECRUITING

Sheboygan, Wisconsin, 53081, United States
Saint Vincent Hospital Cancer Center at Sturgeon Bay
RECRUITING

Sturgeon Bay, Wisconsin, 54235-1495, United States
San Juan City Hospital
RECRUITING

San Juan, 00936, Puerto Rico
Sheboygan Physicians Group
RECRUITING

Sheboygan, Wisconsin, 53081, United States
Stony Brook University Medical Center
RECRUITING

Stony Brook, New York, 11794, United States
Swedish Cancer Institute-Edmonds
RECRUITING

Edmonds, Washington, 98026, United States
Swedish Cancer Institute-Issaquah
RECRUITING

Issaquah, Washington, 98029, United States
Swedish Medical Center-First Hill
RECRUITING

Seattle, Washington, 98122, United States
The James Graham Brown Cancer Center at University of Louisville
RECRUITING

Louisville, Kentucky, 40202, United States
Thomas Jefferson University Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

Contact Email: •••••@•••••
Trinity Health IHA Medical Group Hematology Oncology - Brighton
RECRUITING

Brighton, Michigan, 48114, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton
RECRUITING

Canton, Michigan, 48188, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
RECRUITING

Chelsea, Michigan, 48118, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
RECRUITING

Ypsilanti, Michigan, 48197, United States
Trinity Health Saint Joseph Mercy Oakland Hospital
RECRUITING

Pontiac, Michigan, 48341, United States
Trinity Health Saint Mary Mercy Livonia Hospital
RECRUITING

Livonia, Michigan, 48154, United States
Tufts Medical Center
RECRUITING

Boston, Massachusetts, 02111, United States
UC Comprehensive Cancer Center at Silver Cross
RECRUITING

New Lenox, Illinois, 60451, United States

Contact Email: •••••@•••••
UCSF Medical Center-Parnassus
RECRUITING

San Francisco, California, 94143, United States
UChicago Medicine Northwest Indiana
RECRUITING

Crown Point, Indiana, 46307, United States

Contact Email: •••••@•••••
UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
United Hospital
RECRUITING

Saint Paul, Minnesota, 55102, United States
University of Arizona Cancer Center-North Campus
RECRUITING

Tucson, Arizona, 85719, United States
University of Arkansas for Medical Sciences
RECRUITING

Little Rock, Arkansas, 72205, United States
University of Chicago Comprehensive Cancer Center
RECRUITING

Chicago, Illinois, 60637, United States

Contact Email: •••••@•••••
University of Chicago Medicine-Orland Park
RECRUITING

Orland Park, Illinois, 60462, United States

Contact Email: •••••@•••••
University of Illinois
RECRUITING

Chicago, Illinois, 60612, United States
University of Kansas Cancer Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Kansas Clinical Research Center
RECRUITING

Fairway, Kansas, 66205, United States
University of Kansas Hospital-Westwood Cancer Center
RECRUITING

Westwood, Kansas, 66205, United States
University of New Mexico Cancer Center
RECRUITING

Albuquerque, New Mexico, 87106, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Rochester
RECRUITING

Rochester, New York, 14642, United States
UofL Health Medical Center Northeast
RECRUITING

Louisville, Kentucky, 40245, United States

Contact Email: •••••@•••••
VCU Massey Comprehensive Cancer Center
RECRUITING

Richmond, Virginia, 23298, United States
Wake Forest University Health Sciences
RECRUITING

Winston-Salem, North Carolina, 27157, United States
William S Middleton VA Medical Center
RECRUITING

Madison, Wisconsin, 53705, United States

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