Knee pain relief: study tests if ibuprofen ruins injection benefits
NCT ID NCT06911359
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at whether taking ibuprofen (a common painkiller) along with dextrose prolotherapy injections affects pain and function in people with knee osteoarthritis. Researchers will give 68 adults either ibuprofen or a placebo for 7 days after each of three injections. They will measure pain and knee function using questionnaires over 12 weeks to see if the ibuprofen changes how well the injections work.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- dextrose prolotherapy injection and oral ibuprofen
- What this could lead to
- If it works, this could show that taking ibuprofen along with dextrose prolotherapy is safe and does not reduce the injection's pain-relieving effects for knee osteoarthritis.
- What could go wrong
- This is a small, early-phase trial with only 68 participants, so results may not apply to everyone. It is testing a common combination, not a new breakthrough, and the primary goal is to see if ibuprofen interferes with the injection, not to cure the condition.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for KNEE OSTEOARTHRITIS (OA) are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
David Grant USAF Medical Center
RECRUITINGTravis AFB, California, 94535, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A gentle pull: could manual traction speed up knee replacement recovery?
- Could a simple tool and exercise ease knee arthritis pain without drugs?
- Can dry needling or taping boost strength training for knee arthritis?
- Acupuncture showdown: which needle works best for aching knees?
- New registry aims to see if blocking knee arteries eases arthritis pain
- Knee surgery showdown: is the tourniquet outdated?