Knee pain relief: study tests if ibuprofen ruins injection benefits
NCT ID NCT06911359
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at whether taking ibuprofen (a common painkiller) along with dextrose prolotherapy injections affects pain and function in people with knee osteoarthritis. Researchers will give 68 adults either ibuprofen or a placebo for 7 days after each of three injections. They will measure pain and knee function using questionnaires over 12 weeks to see if the ibuprofen changes how well the injections work.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
dextrose prolotherapy injection and oral ibuprofen
What this could lead to
If it works, this could show that taking ibuprofen along with dextrose prolotherapy is safe and does not reduce the injection's pain-relieving effects for knee osteoarthritis.
What could go wrong
This is a small, early-phase trial with only 68 participants, so results may not apply to everyone. It is testing a common combination, not a new breakthrough, and the primary goal is to see if ibuprofen interferes with the injection, not to cure the condition.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Locations
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David Grant USAF Medical Center
RECRUITINGTravis AFB, California, 94535, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••