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Which RA drug keeps patients on board longer? new study aims to find out

NCT ID NCT06712628

Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 2 times

Summary

This study tracks about 678 adults with moderate to severe rheumatoid arthritis in Germany to see how long they stay on either upadacitinib or TNF inhibitors. Doctors choose the treatment before the study starts, based on standard care. The goal is to learn which drug people stick with longer in everyday practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 678 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2024

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants with moderate to severe active Rheumatoid Arthritis receiving Upadcitinib or a Tumor necrosis factor inhibitor treatment.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Current or Past participants with a confirmed diagnosis of moderate to severe active RA upon judgement of the treating physician. * Physician decision on participant treatment with Upadacitinib (UPA) or tumor necrosis factor inhibitor (TNFi) must have been reached prior to and independently of recruitment in the study * UPA or TNFi prescribed in accordance with the applicable approved label and local regulatory and reimbursement policies Exclusion Criteria: * Participation in a clinical trial with an investigational drug (within a minimum of 30 days or 5 half-lives of the investigational drug \[whichever is longer\] prior to baseline) * Prior treatment with Upadacitinib * Prior treatment with the same tumor necrosis factor inhibitor as the one prescribed for this study

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Conditions

The condition(s) this trial relates to.

rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Moderate to severe rheumatoid arthritis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    71 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Cellitinnen-Krankenhaus St. Josef /ID# 275926

    RECRUITING

    Wuppertal, 42105, Germany

  • Deutsches Endokrinologisches Versorgungszentrum DEVZ - MVZ GdR /ID# 274291

    RECRUITING

    Frankfurt am Main, Hesse, 60329, Germany

  • Die Fachaerzte im Rottal - Nephrologie, Rheumatologie /ID# 284221

    RECRUITING

    Pfarrkirchen, 84347, Germany

  • Dr. Ann-Dorthe Holst /ID# 285741

    RECRUITING

    Ludwigslust, Mecklenburg-Vorpommern, 19288, Germany

  • Dr. Harmuth /ID# 273401

    RECRUITING

    Marktredwitz, Bavaria, 95615, Germany

  • Dr. Med. Thomas Marycz /ID# 274646

    RECRUITING

    Amberg, Bavaria, 92224, Germany

  • Dr. Mueller /ID# 273081

    RECRUITING

    Freiberg, Saxony, 09599, Germany

  • Dr. Murawski /ID# 272724

    RECRUITING

    Neunkirchen, Saarland, 66538, Germany

  • Fachpraxis fur Rheumatologie und Osteologie /ID# 275359

    RECRUITING

    Weyhe, Lower Saxony, 28844, Germany

  • Gemeinschaftspraxis Innere Medizin/Rheumatologie /ID# 278584

    RECRUITING

    Freiburg im Breisgau, Baden-Wurttemberg, 79098, Germany

  • Gesundheitscampus Monheim /ID# 283726

    RECRUITING

    Monheim am Rhein, North Rhine-Westphalia, 40789, Germany

  • Klinikum Bielefeld Rosenhohe /ID# 283715

    RECRUITING

    Bielefeld, North Rhine-Westphalia, 33647, Germany

  • Klinische Forschung Im Medizinischen Versorgungalltag Gbr /ID# 274587

    RECRUITING

    Planegg, Bavaria, 82152, Germany

  • Knappschaftsklinikum Saar /ID# 279852

    RECRUITING

    Püttlingen, Saarland, 66346, Germany

  • MVZ Herzogin Elisabeth Hospital /ID# 272725

    RECRUITING

    Braunschweig, 38114, Germany

  • MVZ Weserbergland /ID# 276009

    COMPLETED

    Bad Pyrmont, 31812, Germany

  • MVZ-Medizinisches Versorgungszentrum Daun GmbH /ID# 285725

    RECRUITING

    Daun, 54550, Germany

  • Medikomp Mvz /ID# 285898

    RECRUITING

    Elsterwerda, Brandenburg, 04910, Germany

  • Medizinischen Versorgungszentrums Agilomed /ID# 274887

    RECRUITING

    Chemnitz, Saxony, 09130, Germany

  • Mvz Dr. Med. Mahdy and Kollegen - Braunschweig /ID# 284988

    RECRUITING

    Braunschweig, Lower Saxony, 38106, Germany

  • Praxis Barmen /ID# 277514

    RECRUITING

    Wuppertal, 42285, Germany

  • Praxis Dilltal /ID# 272727

    RECRUITING

    Ehringshausen, 35630, Germany

  • Praxis Dr. med. Florian Beyer /ID# 274293

    RECRUITING

    Kaiserslautern, Rhineland-Palatinate, 67657, Germany

  • Praxis F. Schattenberg /ID# 280322

    RECRUITING

    Waren, 17192, Germany

  • Praxis Fiene /ID# 279410

    RECRUITING

    Greifswald, 17493, Germany

  • Praxis H. Fricke-Wagner /ID# 274467

    RECRUITING

    Zwickau, Saxony, 08056, Germany

  • Praxis K. Pagel /ID# 279121

    RECRUITING

    Hoppegarten, Brandenburg, 15366, Germany

  • Praxis. F. Bigdeli-Wilshusen /ID# 273455

    RECRUITING

    Hanover, Lower Saxony, 30173, Germany

  • Praxiszentrum Dr. Med. Klaus Kruger Dres. Günther Kellerer Und Paul Kellerer /ID# 276138

    RECRUITING

    Munich, Bavaria, 81541, Germany

  • Private Practice - Dr. Alexander Lautwein /ID# 282328

    RECRUITING

    Wittlich, Rhineland-Palatinate, 54516, Germany

  • Private Practice - Dr. Christine Baumann /ID# 275095

    RECRUITING

    Plauen, Saxony, 08523, Germany

  • Private Practice - Dr. Daniel Bestler /ID# 272741

    RECRUITING

    Erfurt, 99096, Germany

  • Private Practice - Dr. Dirk Wernicke /ID# 276820

    RECRUITING

    Hohen Neuendorf, Brandenburg, 16540, Germany

  • Private Practice - Dr. Frank Hamann, Dr. Andreas Teich & Dr. Konrad Boche /ID# 275358

    RECRUITING

    Leipzig, Saxony, 04109, Germany

  • Private Practice - Dr. Hauke E. Heintz /ID# 278081

    RECRUITING

    Hamburg, 22391, Germany

  • Private Practice - Dr. Ilka Schwarze /ID# 276981

    RECRUITING

    Leipzig, Saxony, 04129, Germany

  • Private Practice - Dr. Jochen Walter /ID# 280069

    RECRUITING

    Rendsburg, Schleswig-Holstein, 24768, Germany

  • Private Practice - Dr. Jorg Sensse /ID# 281907

    RECRUITING

    Gifhorn, Lower Saxony, 38518, Germany

  • Private Practice - Dr. Sebastian Schuh /ID# 272731

    RECRUITING

    Coburg, 96450, Germany

  • Private Practice - Dr. Silke Zinke /ID# 276366

    RECRUITING

    Berlin, 13055, Germany

  • Private Practice - Dr. Thilo Klopsch - Stargarder Strasse /ID# 276367

    RECRUITING

    Neubrandenburg, Mecklenburg-Vorpommern, 17033, Germany

  • Private Practice - Dr. Thomas Kupka /ID# 273631

    RECRUITING

    Altenburg, Thuringia, 04600, Germany

  • Private Practice- Dr. Joerdis Gerigk /ID# 283747

    RECRUITING

    Magdeburg, Saxony-Anhalt, 39106, Germany

  • Prof-med-stud.de /ID# 285869

    RECRUITING

    Munich, 80935, Germany

  • Rheumahaus Studien GbR /ID# 275917

    RECRUITING

    Potsdam, Brandenburg, 14467, Germany

  • Rheumapraxis Am Webereck /ID# 274412

    RECRUITING

    Augsburg, Bavaria, 86157, Germany

  • Rheumapraxis An Der Hase /ID# 276949

    RECRUITING

    Osnabrück, Lower Saxony, 49074, Germany

  • Rheumapraxis Dr. Liebhaber /ID# 274888

    RECRUITING

    Halle, Saxony-Anhalt, 06128, Germany

  • Rheumapraxis Dr. Prothmann /ID# 279851

    RECRUITING

    Püttlingen, Saarland, 66346, Germany

  • Rheumapraxis Düren /ID# 272726

    RECRUITING

    Düren, 52355, Germany

  • Rheumapraxis Haas Tubingen /ID# 275536

    RECRUITING

    Tübingen, Baden-Wurttemberg, 72072, Germany

  • Rheumapraxis Hannover-List /ID# 273735

    RECRUITING

    Hanover, Lower Saxony, 30161, Germany

  • Rheumapraxis Heidelberg /ID# 276475

    RECRUITING

    Heidelberg, Baden-Wurttemberg, 69120, Germany

  • Rheumapraxis Kaufering /ID# 283852

    RECRUITING

    Kaufering, 86916, Germany

  • Rheumapraxis Steglitz /ID# 280323

    RECRUITING

    Berlin, 12161, Germany

  • Rheumapraxis Ulm Dr. med. Nadia Rinaldi /ID# 276293

    RECRUITING

    Ulm, Baden-Wurttemberg, 89073, Germany

  • Rheumapraxis Weimar /ID# 272740

    RECRUITING

    Weimar, Thuringia, 99427, Germany

  • Rheumapraxis Zweibruecken - Matar /ID# 282656

    RECRUITING

    Zweibrücken, Rhineland-Palatinate, 66482, Germany

  • Rheumapraxis am Schlossberg /ID# 272728

    RECRUITING

    Homburg, Saarland, 66424, Germany

  • Rheumatism Center Mittelhessen /ID# 274641

    RECRUITING

    Bad Endenbach, Hesse, 35080, Germany

  • Rheumatologie Kassel /ID# 275916

    RECRUITING

    Kassel, Lower Saxony, 34125, Germany

  • Rheumatologisch Immunologisch /ID# 275830

    RECRUITING

    Templin, Brandenburg, 17268, Germany

  • Rheumatologische Facharztpraxis - Magdeburg /ID# 272866

    RECRUITING

    Magdeburg, Saxony-Anhalt, 39104, Germany

  • Rheumatologische Facharztpraxis - Naumburg (Saale) /ID# 272743

    RECRUITING

    Naumburg, Saxony-Anhalt, 06618, Germany

  • Rheumatologische Facharztpraxis - Schwerin /ID# 284785

    RECRUITING

    Schwerin, Mecklenburg-Vorpommern, 19053, Germany

  • Rheumatologische Facharztpraxis /ID# 286591

    RECRUITING

    Hanover, Lower Saxony, 30159, Germany

  • Rheumatology Euskirchen /ID# 285419

    RECRUITING

    Euskirchen, North Rhine-Westphalia, 53879, Germany

  • Rheumazentrum Ratingen /ID# 275707

    RECRUITING

    Ratingen, North Rhine-Westphalia, 40882, Germany

  • Rheumazentrum Ruhrgebiet /ID# 275518

    RECRUITING

    Herne, North Rhine-Westphalia, 44649, Germany

  • Schwerpunktpraxis Rheumatologie und Klinische Immunologie /ID# 282628

    RECRUITING

    Dresden, Saxony, 01097, Germany

  • St.Elisabeth Hospital Meerbusch /ID# 275030

    RECRUITING

    Meerbusch, North Rhine-Westphalia, 40668, Germany

  • Stadtisches Klinikum Braunschweig /ID# 282626

    RECRUITING

    Braunschweig, Lower Saxony, 38126, Germany

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