Massive study aims to unlock secrets of rare inflammatory diseases

NCT ID NCT02974595

Recruiting now Knowledge-focused Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is for people with certain autoinflammatory diseases (like NOMID, DIRA, CANDLE, SAVI, and others) and their healthy relatives. Researchers want to learn more about what causes these diseases and how they affect the body over time. Participants will have medical tests and check-ups at the NIH, with follow-up visits for up to 15 years.

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Conditions

The condition(s) this trial relates to.

CINCA syndrome cryopyrin-associated periodic syndrome periodic fever-infantile enterocolitis-autoinflammatory syndrome proteosome-associated autoinflammatory syndrome sterile multifocal osteomyelitis with periostitis and pustulosis STING-associated vasculopathy with onset in infancy systemic-onset juvenile idiopathic arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CANDLE DIRA NLRC4-MAS NOMID SAVI

Contacts and locations

Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

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