Non-syndromic limb reduction defect

This trial tests a gene therapy for Fanconi anemia, a rare genetic disorder that causes bone marrow failure and increases cancer risk. Participants receive their own stem cells that have been genetically corrected with a lentiviral vector to fix the faulty FANCA gene. The study e…

This study compares two common surgeries for correcting clubfoot in children aged 2-5 who have not been treated before. The goal is to see which method better improves ankle movement and has fewer complications like bleeding or infection. About 44 children will take part, and res…

This trial compares two surgical tools—a standard surgical blade and a special ophthalmic knife—for cutting the Achilles tendon in children aged 2 to 5 with clubfoot. The goal is to see which tool improves ankle movement more and causes fewer problems like bleeding or infection. …

Club foot is a common birth defect where a baby's foot is twisted out of shape. The standard treatment uses weekly plaster casts to gradually correct the foot. This study tests whether changing the cast twice a week instead of once works just as well or better. About 144 babies u…

This study tests a 16-week inclusive exercise program called PACE for adults with intellectual disability. Participants will attend fitness classes, meet with coaches, and use a web dashboard to set goals. The trial includes 376 people and will measure daily steps and moderate-to…

This study tests a new breast reconstruction method for women who have had breast cancer or have Poland syndrome. The approach uses a special tissue expander to stretch the skin, followed by fat grafting from the patient's own body, and finally a permanent breast implant. The goa…

This trial tests a wearable robot called ENMS-BSF that combines soft muscles, electrical stimulation, and balance feedback to correct foot drop and foot inversion after a stroke. Sixty people who had a stroke at least six months ago and have mild-to-moderate walking problems will…

This study looks at whether doing breathing exercises before orthopedic surgery (like knee, hip, or fracture repair) can help your lungs work better after the operation. It involves 36 adults who have used tobacco and are at risk for breathing problems after surgery. Participants…

This study tests whether a program of exercise and ergonomics training can reduce muscle and joint pain in teachers. About 80 teachers who have had pain for at least three months will be randomly assigned to receive the training or not. Researchers will measure changes in pain, d…

This study looks at whether adding a foot abduction brace to the French method (a stretching and taping technique) helps babies with clubfoot more than the French method alone. Researchers will enroll 18 infants under 12 months old who have not had prior treatment. They will meas…

This study tests if a less invasive freezing technique (cryoneurotomy) works as well as surgery to reduce foot stiffness in people who had a stroke. About 114 adults with chronic foot spasticity will be randomly assigned to one of the two treatments. The goal is to see if the fre…

This study tests whether applying Mastisol, a liquid adhesive, during clubfoot casting helps babies with clubfeet get better faster and with fewer problems. Researchers will compare outcomes like how many weeks of casting are needed and how often complications like sores or swell…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study looks at whether a prosthetic knee with a built-in computer (microprocessor-controlled) can help people with above-knee amputations have fewer fall-related problems, walk faster, and feel better overall. About 100 adults who already use a basic prosthetic knee will eit…

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This study aims to learn more about rare skeletal disorders by collecting medical records, blood samples, and genetic data from 100 participants. People with known or suspected bone conditions, as well as their healthy family members, can join either remotely or in person. The go…

This study looks at how people who have lost an arm or were born without one experience phantom limb sensations—like feeling their missing hand move. Researchers will interview participants and map these sensations to help design prosthetics that are easier to control and feel mo…

This natural history study follows up to 4,000 people with inherited bone marrow failure syndromes (IBMFS) and their families to learn why they are prone to certain cancers. Researchers will track health over time, collect genetic samples, and look for clues that separate those w…

This study translates and tests several health questionnaires—covering pain, arm and leg function, mood, and daily activities—for use with Albanian-speaking people. Researchers will check if the translated versions are reliable and accurate by giving them to about 300 participant…

This study is creating a collection of blood, urine, and leftover surgical tissue from 350 patients with bone, calcium, and growth plate disorders. The goal is to better understand how these diseases progress and to find markers that could predict outcomes. No new treatments are …

This study tests a new tool called the PRISM Dashboard, which gives physiotherapists feedback on how their decisions compare to their peers. The goal is to see if this feedback helps reduce differences in care for people with muscle and joint pain. About 60 physiotherapists and t…

This pilot study looks at how botulinum toxin (Botox) injections affect the muscles, tendons, and nerves in the feet of people who have had a stroke and developed a tight, twisted foot (equinovarus). Researchers will use special ultrasound and movement tests to track these change…

This study follows 252 adults with muscle, bone, or joint problems (like arthritis, back pain, or after surgery) to see how well they do their prescribed home exercises. Researchers will track who sticks with the program and why, looking at factors like pain, mood, and support. T…

This study tests whether using a virtual reality (VR) headset during shoulder exercises helps patients feel more engaged and motivated. Fifty adults with shoulder problems will do rehab exercises in a VR environment and then answer questionnaires about how easy and immersive the …

This study aims to find genes that cause eye misalignment (strabismus) and related conditions involving the cranial nerves and brainstem. Researchers will analyze DNA from up to 20,000 participants with these disorders. The goal is to better understand the genetic causes, which c…

This study aims to create a secure national database for muscle and joint (musculoskeletal) conditions by collecting routine data from community clinics and GP practices. About 22,000 adults will have their information anonymously gathered to help develop a dashboard that tracks …

This study watches 2000 people having hip or knee replacement surgery to see how long spinal anaesthesia lasts. The goal is to learn how the amount of anaesthetic affects timing, helping doctors decide if patients can safely go home the same day. No new treatments are tested—just…

This study looks at how changing the heel cushion on an ankle-foot brace (AFO) affects walking in people who use one daily. Forty adults with leg injuries or nerve problems will try four different heel wedges—tall or short, soft or firm—while walking at controlled speeds. Researc…

This study looks at how 3D computer simulation and printing can help surgeons better plan and perform bone correction surgeries. Researchers will compare the planned corrections to the actual results in 100 children and young adults with rare bone deformities. The goal is to make…

This study follows 4,000 children who receive orthopedic implants (like rods or screws) during standard care for bone fractures, deformities, or hip problems. Researchers will track how long the implants last, any complications, and how well they work over time. The goal is to ga…

This study is building a registry of people with rare bone diseases (skeletal dysplasias) in Italy. Researchers will collect medical history, genetic data, and treatment details over time to better understand how these conditions progress. No experimental treatments are given; th…

This study follows 144 adults with muscle or bone problems who are already scheduled to receive treatment with Chattanooga Intelect devices (like TENS or ultrasound). Researchers will measure pain, muscle strength, and movement range to confirm the devices are safe and work as ex…

This study looks at how the brain changes in people born without a hand or upper limb. Researchers will use brain scans and simple tasks to compare their brain activity and structure to those with both arms. The goal is to understand how early life shapes the brain's ability to a…

This study aims to find the best way to place sensors on a prosthetic socket to improve how well people with below-elbow amputations can control their powered arm. Researchers will compare different numbers of sensors (4, 8, or up to 16) and whether targeting specific muscles hel…

This study tests whether powered prosthetic knees help people with above-knee amputations walk more and feel more confident than standard non-powered knees. Twenty-six adults who already use a mechanical knee will try both types at home for three months each. Researchers will tra…