Holt-Oram syndrome

MONDO:0007732

Holt-Oram syndrome (HOS) is the most common form of heart-hand syndrome and is characterized by skeletal abnormalities of the upper limbs and mild-to-severe congenital cardiac defects.

Also known as: atrio digital syndrome, atrio-digital syndrome, atriodigital dysplasia, heart-hand syndrome, HOLT-Oram syndrome, HOS, Holt Oram Syndrome, Holt-Oram syndrome

1 clinical trial for this condition and its sub-types, 0 tagged with Holt-Oram syndrome itself.

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Where it sits in the disease tree

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Part of

↑ Autosomal dominant disease (699) ↑ Cardiogenetic disease (614) ↑ Multiple congenital anomalies/dysmorphic syndrome without intellectual disability (163) ↑ Non-syndromic limb reduction defect (35) ↑ Heart-hand syndrome (0)

Sub-types of Holt-Oram syndrome

Heart-hand syndrome type 3 0 trials

Including sub-types (1) Tagged with Holt-Oram syndrome (0)

Completed 1

Kids test new bionic foot design

Knowledge-focused Completed

This study tested a new prosthetic foot for children with leg amputations or birth defects. Thirteen kids walked with the device and gave feedback on stiffness and performance. The goal was to gather ideas to improve future foot designs.

Sponsor: Össur Iceland ehf • Aim: Knowledge-focused

Last updated Jun 27, 2026 14:00 UTC

Holt-Oram syndrome

Where it sits in the disease tree

Kids test new bionic foot design