Can a Patient's own immune cells fight advanced sarcoma?
NCT ID NCT07741877
First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time
Summary
This phase 2 trial is testing whether lifileucel, a therapy made from a patient's own tumor-infiltrating lymphocytes (immune cells), can shrink tumors in adults with advanced soft tissue sarcoma. Participants will have their tumor removed to create the personalized therapy, then receive a short course of chemotherapy followed by the lifileucel infusion and a brief course of aldesleukin. The study focuses on two types of sarcoma: undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma, and will measure how many patients respond to treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- lifileucel (tumor-infiltrating lymphocytes, also known as LN-145), given after a preparative chemotherapy regimen and followed by a short course of aldesleukin (interleukin-2)
- What this could lead to
- If successful, this could offer a new treatment option for people with advanced soft tissue sarcoma, potentially shrinking tumors and improving outcomes.
- What could go wrong
- This is a phase 2 trial, so the treatment may not work for everyone and could have significant side effects, including reactions to the chemotherapy and immune-related effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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