Can you cut your arthritis meds without flaring up? new trial aims to find out

NCT ID NCT07160231

Recruiting now Disease control Sponsor: Sint Maartenskliniek Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study looks at whether people with rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis who are doing well on a JAK inhibitor can safely reduce their dose. About 200 participants will either lower their dose or stay on the same dose, guided by disease activity. The goal is to see if the lower dose keeps the disease under control just as well after 12 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: JAK inhibitor dose reduction strategy
What this could lead to: If successful, this could show that many patients can safely lower their JAK inhibitor dose without losing disease control, reducing side effects and costs.
What could go wrong: This is a Phase 4 trial with 200 participants, so results may not apply to everyone. Lowering the dose might lead to disease flares in some patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Axial Spondyloarthritis psoriatic arthritis rheumatoid arthritis spondyloarthropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AXIAL SPONDYLOARTHRITIS (AXSPA) PSORIATIC ARTHRITIS (PSA) RHEUMATOID ARTHRITIS (RA)

Contacts and locations

Locations

Elisabeth-TweeSteden Ziekenhuis Tilburg
NOT_YET_RECRUITING

Tilburg, North Brabant, 5022 GC, Netherlands
Erasmus MC
NOT_YET_RECRUITING

Rotterdam, South Holland, 3015 GD, Netherlands
Isala Zwolle
NOT_YET_RECRUITING

Zwolle, Overijssel, 8025 AB, Netherlands
Maasstad ziekenhuis
NOT_YET_RECRUITING

Rotterdam, South Holland, 3079 DZ, Netherlands
Maastricht UMC+
NOT_YET_RECRUITING

Maastricht, Limburg, 6229 HX, Netherlands
Medisch Spectrum Twente
NOT_YET_RECRUITING

Enschede, Overijssel, 7512 KZ, Netherlands
Sint Maartenskliniek Nijmegen
RECRUITING

Nijmegen, Gelderland, 6574 NA, Netherlands

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