Could an asthma drug shield knees from arthritis after ACL surgery?
NCT ID NCT04572256
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This trial investigates whether montelukast, a common asthma medication, can reduce inflammation and prevent cartilage breakdown after anterior cruciate ligament (ACL) reconstruction. The study enrolls adults aged 25 to 50 who also have a meniscus tear, a group at high risk for rapid osteoarthritis. Participants take either montelukast or a placebo daily for six months after surgery, and researchers measure markers of inflammation and cartilage health using blood tests, MRI scans, and patient questionnaires.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
montelukast (Singulair)
What this could lead to
If it works, this could point toward a simple, inexpensive way to prevent post-traumatic osteoarthritis after ACL surgery.
What could go wrong
This is a very early, small trial (30 people) testing a drug not originally designed for joints. The results may not lead to a proven treatment.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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UK Healthcare at Turfland
RECRUITINGLexington, Kentucky, 40504, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact