New knee implant aims for 10-Year durability in arthritis patients

NCT ID NCT07199738

Recruiting now Disease control Sponsor: Smith & Nephew, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 07, 2026 · Updated 4 times

Summary

This study is testing the LEGION Medial Stabilized knee implant in 144 people who need total knee replacement due to arthritis or joint damage. The goal is to see how well the implant holds up over 10 years without needing revision surgery. Participants will receive one of three versions of the implant, and their progress will be tracked for up to a decade.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: LEGION Medial Stabilized knee implant (device)
What this could lead to: If successful, this could confirm that the LEGION knee implant is safe and durable for long-term use, helping people with arthritis or joint damage get back to daily activities.
What could go wrong: This is a mid-stage study with only 144 participants, so results may not apply to everyone. There is always a risk of implant failure, infection, or need for revision surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

arthritic joint disease osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFLAMMATORY ARTHRITIS POST-TRAUMATIC ARTHRITIS PRIMARY TOTAL KNEE ARTHROPLASTY DUE TO DEGENERATIVE JOINT DISEASE (PRIMARY DIAGNOSIS OF OSTEOARTHRITIS)

Contacts and locations

Locations

Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
New York University Hospital
RECRUITING

New York, New York, 10016, United States
Newton Wellesley Hospital
RECRUITING

Newton, Massachusetts, 02462, United States
University of Wisconsin
NOT_YET_RECRUITING

Madison, Wisconsin, 53715-1218, United States

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