Could a simple pill ease pain after knee surgery?

NCT ID NCT04576078

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether taking nefopam, a non-opioid painkiller, by mouth before and after knee replacement surgery can reduce pain and the need for morphine. About 50 adults having knee replacement will be randomly assigned to receive either nefopam or a placebo. The goal is to see if this approach leads to better pain control and fewer side effects.

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Conditions

The condition(s) this trial relates to.

Hyperalgesia osteoarthritis osteoarthritis, knee Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Département d'Anesthésie Réanimation, Groupement Hospitalier Nord, Hospices Civils de Lyon

    RECRUITING

    Lyon, Lyon, 69004, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact