Could a simple pill ease pain after knee surgery?
NCT ID NCT04576078
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether taking nefopam, a non-opioid painkiller, by mouth before and after knee replacement surgery can reduce pain and the need for morphine. About 50 adults having knee replacement will be randomly assigned to receive either nefopam or a placebo. The goal is to see if this approach leads to better pain control and fewer side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ADVANCED GONARTHROSIS (STAGE III) are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Département d'Anesthésie Réanimation, Groupement Hospitalier Nord, Hospices Civils de Lyon
RECRUITINGLyon, Lyon, 69004, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- New knee implant under Real-World scrutiny: will it deliver better outcomes?
- Knee replacement pain study aims to cut chronic pain risk
- Brain scans reveal why some knee pain feels different
- Ozone injection study: does concentration matter for knee pain?
- Smartphone surveys could replace paper forms for knee surgery Follow-Up
- Knee replacement recovery: which pain block gets you walking faster?