OSTEO ARTHRITIS KNEE

This early-phase study tested whether a single injection of donor bone-marrow stem cells (StromaForte) is safe for people with mild-to-moderate knee osteoarthritis. Twelve adults received the injection and were monitored for side effects over 24 weeks. The main goal was safety, n…

This study tests a wearable device that delivers low-intensity ultrasound to the knee for 1-4 hours daily, combined with a diclofenac pain patch, to reduce pain and improve function in people with mild-to-moderate knee osteoarthritis. Participants aged 50-85 with frequent knee pa…

This study tested whether adding a special breathing therapy (intermittent hypoxia-hyperoxia) to standard physical therapy helps people with knee osteoarthritis. Sixty adults aged 45 and older with knee pain for at least 3 months took part. The breathing therapy involved short cy…

This study compared a single injection of sterile amniotic fluid to the standard steroid shot for knee osteoarthritis. 60 adults with moderate knee arthritis who had not gotten relief from other treatments took part. The main goal was to see if the amniotic fluid could reduce the…

This study tested whether using a cold and compression brace for six weeks after knee replacement surgery helps reduce pain and the need for painkillers. 208 patients who had a total or partial knee replacement were asked to use the brace five times a day for up to 20 minutes. Re…

This early study tested whether injecting a special mixture of cells from a person's own belly fat into their arthritic knee is safe and doable. Nine adults with knee osteoarthritis received the injection. The main goal was to check for side effects, not to measure pain relief, s…

This phase 3 study tested a weekly injection called retatrutide in 445 people who are overweight or have obesity and also have knee osteoarthritis. The goal was to see if it reduces knee pain and helps with weight loss. Participants received either the drug or a placebo for about…

This study tested a movement therapy called Mulligan mobilization in 36 people with knee osteoarthritis. The goal was to see if it could reduce pain and improve how muscles work. Participants were aged 50 to 70 with moderate knee pain. The therapy involves gentle, repeated moveme…

This study looked at whether adding deep breathing or simple yoga poses to standard physical therapy could help people with knee osteoarthritis feel less afraid of moving. 40 adults aged 40-60 with severe knee pain took part. The results showed that both approaches helped reduce …

This study tested a portable device called the OrthoCor Advanced System in 23 people with knee osteoarthritis. The device delivers pulsed electromagnetic fields and heat to the knee, and users track their progress with a smartphone app. Researchers measured pain, range of motion,…

This Phase 2 trial tested a drug called LEVI-04 in 518 adults with knee osteoarthritis. The drug is designed to block pain signals. Researchers measured pain changes using a standard knee pain scale. The goal is to see if LEVI-04 can safely reduce pain and improve daily function.

This study tested a two-week home treatment combining gentle brain stimulation (tDCS) with mindfulness meditation in 208 older adults with knee osteoarthritis. The goal was to see if this drug-free approach could reduce pain and improve daily function. Results focused on changes …

This study tested whether adding a gentle joint-gliding technique called Mulligan's mobilization to simple isometric exercises could help people with knee osteoarthritis. Fifty adults with moderate knee arthritis received either the mobilization plus exercises or a sham version f…

This study tested whether adding a topical gel (diclofenac) to a supervised exercise program helps knee osteoarthritis pain more than exercise or gel alone. 79 adults aged 40-65 with mild to moderate knee osteoarthritis took part. The results could help doctors recommend better n…

This study tested a personalized web-based care plan for over 5,700 adults with knee or hip osteoarthritis. The goal was to help patients and their doctors make more informed decisions about treatments, including whether to have joint replacement surgery. The study measured how w…

This study looked at 60 people with knee osteoarthritis to see if testing muscle strength while doing a second task (dual task) gives different results than testing strength alone. Participants were between 40 and 65 years old and had moderate knee OA. The researchers measured le…