Knee pain relief: exercise plus gel beats either alone

NCT ID NCT05827003

Completed Symptom relief Sponsor: Istanbul University - Cerrahpasa Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether adding a topical gel (diclofenac) to a supervised exercise program helps knee osteoarthritis pain more than exercise or gel alone. 79 adults aged 40-65 with mild to moderate knee osteoarthritis took part. The results could help doctors recommend better non-surgical treatment plans.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: diclofenac gel
What this could lead to: If successful, this could show that combining exercise with a topical gel is a more effective way to manage knee osteoarthritis pain than either treatment alone.
What could go wrong: This is a small, completed trial with 79 participants. Results may not apply to everyone, and the study does not test long-term effects or compare with other common treatments like oral painkillers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEO ARTHRITIS KNEE

Contacts and locations

Locations

Istanbul University-Cerrahpasa

Istanbul, Istanbul, 34500, Turkey (Türkiye)

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