Can exercise or a gel soothe knee arthritis pain?
NCT ID NCT05827003
First seen Nov 01, 2025 · Last updated Jun 22, 2026 · Updated 35 times
Summary
This study tested whether supervised exercise, a diclofenac gel, or both together work better for knee osteoarthritis pain and function. 79 adults aged 40-65 with mild to moderate knee OA took part. The goal was to see which approach offers the most relief for this common, painful condition.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Istanbul University-Cerrahpasa
Istanbul, Istanbul, 34500, Turkey (Türkiye)
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
diclofenac gel
What this could lead to
If the combination works best, it could point to a simple, drug-free way to improve pain and mobility without surgery.
What could go wrong
This is a small, completed trial with only 79 people, so results may not apply to everyone. Exercise and gel only ease symptoms, not cure the disease.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.