New weekly shot could shed pounds and soothe aching knees

NCT ID NCT05931367

Completed Symptom relief Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 study tested a weekly injection called retatrutide in 445 people who are overweight or have obesity and also have knee osteoarthritis. The goal was to see if it reduces knee pain and helps with weight loss. Participants received either the drug or a placebo for about 77 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Retatrutide (a weekly injection)
What this could lead to: If it works, this could offer a new treatment that helps with both weight loss and knee pain from osteoarthritis.
What could go wrong: This is a completed phase 3 trial, but results are not yet published. The drug may cause side effects or not work better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder osteoarthritis, knee Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY OSTEO ARTHRITIS KNEE OVERWEIGHT

Contacts and locations

Locations

ALPHA Recherche Clinique

Québec, G3K 2P8, Canada
Alpha Recherche Clinique

Québec, G2J 0C4, Canada
Arizona Research Center

Phoenix, Arizona, 85053, United States
Artemis Institute for Clinical Research

San Diego, California, 92103, United States
Barwon Health

Geelong, Victoria, 3220, Australia
Bluewater Clinical Research Group Inc.

Sarnia, Ontario, N7T 4X3, Canada
C-health Research

Calgary, Alberta, T2V 4J2, Canada
CDH Research Institute

Maroochydore, Queensland, 4558, Australia
CHUAC-Complejo Hospitalario Universitario A Coruña

A Coruña, 15006, Spain
Canadian Phase Onward

Toronto, Ontario, M3J 0K2, Canada
Centro de Estudios de Investigacion Metabolicos y Cardiovasculares

Ciudad Madero, Tamaulipas, 89440, Mexico
Chase Medical Research, LLC

Waterbury, Connecticut, 06708, United States
Clinical Trials of Texas, Inc.

San Antonio, Texas, 78229, United States
Clinvest Research LLC

Springfield, Missouri, 65807, United States
Clínica García Flores SC

Monterrey, Nuevo León, 64610, Mexico
Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)

Seville, 41003, Spain
Complejo Hospitalario Universitario de Ferrol (CHUF)- Hospital Naval")

Ferrol, A Coruña, 15405, Spain
Consultorio Médico

Guadalajara, Jalisco, 44210, Mexico
Core Research Group

Brisbane, Queensland, 4064, Australia
Eastern Health - General Hospital

St. John's, Newfoundland and Labrador, A1B 3V6, Canada
Elite Clinical Trials

Blackfoot, Idaho, 83221, United States
Emeritus Research

Botany, New South Wales, 2019, Australia
Emeritus Research

Camberwell, Victoria, 3124, Australia
Great Lakes Research Group, Inc.

Bay City, Michigan, 48706, United States
Hospital General Universitario de Valencia

Valencia, Valenciana, 46014, Spain
Hospital Quirón Málaga

Málaga, Andalusia, 29004, Spain
Hospital Universitario Infanta Sofía

San Sebastián de los Reyes, Madrid, 28702, Spain
Hospital Universitario Reina Sofia

Córdoba, Andalusia, 14004, Spain
Hospital de la Santa Creu i Sant Pau

Barcelona, Catalonia, 08041, Spain
IMED Internal Medicine Clin Trials

Monterrey, Nuevo León, 64020, Mexico
Investigacion y Biomedicina de Chihuahua

Chihuahua City, 31000, Mexico
Kohler and Milstein Research S.A. de C.V.

Mérida, Yucatán, 97070, Mexico
Leicester General Hospital

Leicester, Leicestershire, LE5 4PW, United Kingdom
MedVadis Research Corporation

Waltham, Massachusetts, 02451, United States
Mercy Family Clinic

Dallas, Texas, 75211, United States
North Georgia Clinical Research

Woodstock, Georgia, 30189, United States
Northwest Clinical Research Center

Bellevue, Washington, 98007, United States
Northwestern University

Chicago, Illinois, 60611, United States
Panthera Biopartners - North London

Enfield, London, EN3 4GS, United Kingdom
Panthera Biopartners - Sheffield

Sheffield, S2 5FX, United Kingdom
Paratus Clinical Research Canberra

Bruce, Australian Capital Territory, 2617, Australia
Paratus Clinical Research Western Sydney

Blacktown, New South Wales, 2148, Australia
Royal Brisbane and Women's Hospital

Brisbane, Queensland, 4029, Australia
Stouffville Medical Research Institute Inc.

Stouffville, Ontario, L4A 1H2, Canada
Suncoast Research Group

Miami, Florida, 33135, United States
Unidad Médica para la Salud Integral

San Nicolás de los Garza, Nuevo León, 66465, Mexico
Viable Clinical Research

Bridgewater, Nova Scotia, B4V 3N2, Canada
Viable Clinical Research

Scarborough Village, Ontario, M1P 2T7, Canada
Wharton Medical Clinic

Hamilton, Ontario, L8L 5G8, Canada

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