LEUKEMIA

This study is testing a new COVID-19 vaccine called GEO-CM04S1 against standard mRNA vaccines in people with blood cancers who have received a stem cell transplant or cellular therapy. The goal is to see if the new vaccine creates a stronger immune response in these vulnerable pa…

This study is testing a drug called neratinib in children and young adults whose solid tumors, brain tumors, lymphoma, or leukemia have returned or did not respond to standard treatments. The main goals are to find a safe dose and see what effects, both good and bad, the drug has…

This was a very early study designed to test the safety and side effects of an experimental drug called MT-0169 in patients with acute leukemia. It was intended for people whose cancer had come back, did not respond to standard treatments, or had small amounts of leftover disease…

This study is testing whether a chemotherapy combination commonly used to treat children with acute lymphoblastic leukemia (ALL) is safe and effective for adults aged 18-60 with newly diagnosed ALL. The goal is to see if this 'pediatric-inspired' approach can help adults achieve …

This early-stage study is testing the safety and best dose of an experimental drug called AZD6738 for adults with myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) that has progressed after initial treatment. The drug works by blocking a specific protein in…

This study is testing a new combination of radiation and chemotherapy given before a donor stem cell transplant for patients with leukemia and related blood cancers. The goal is to see if this new approach is safe and effective at controlling the cancer while reducing complicatio…

This early-stage study is testing a new type of personalized immune cell therapy for children and young adults with a specific type of leukemia that has come back or hasn't responded to other treatments. Doctors take a patient's own immune cells (T-cells), modify them in a lab to…

This study is testing whether combining two drugs—an oral targeted therapy (vemurafenib) and an immunotherapy infusion (obinutuzumab)—can effectively treat adults with hairy cell leukemia who haven't had any prior treatment. The goal is to achieve a complete remission, meaning no…

This early-stage study is testing a new cell therapy called GDX012 for adults with acute myeloid leukemia (AML) that has returned or not responded to prior treatments. The main goals are to find out how safe the treatment is, what side effects patients experience, and to determin…

This study is testing whether combining two existing drugs, lenalidomide and rituximab, can help control chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). It is for adults who are either newly diagnosed and not candidates for standard chemo, or who have had …

This is an early-stage safety study testing a new type of cell therapy for adults with certain recurring B-cell blood cancers (like lymphoma, myeloma, or CLL) that have not responded to standard treatments. Doctors take a patient's own immune cells (T cells), genetically modify t…

This trial is testing a modified stem cell transplant for people with blood cancers like leukemia and lymphoma who don't have a perfectly matched donor. Doctors use a special process to remove certain immune cells from the donor's stem cells before the transplant. The goal is to …

This study is testing whether the drug ruxolitinib can help control Chronic Myelomonocytic Leukemia (CMML), a rare blood cancer. Researchers are enrolling 29 adults with CMML who have significant symptoms or an enlarged spleen. The main goal is to see if the treatment reduces sym…

This study collects a person's own white blood cells to potentially make a future cancer treatment called CAR-T cell therapy. It is for children and adults (ages 3-65) with certain types of leukemia or lymphoma that have not been cured by standard treatments. The collected cells …

This study is testing whether two drugs, palifermin and leuprolide acetate, can help a patient's immune system recover more quickly after receiving a stem cell transplant from a donor. The transplant is for patients with blood cancers like leukemia or lymphoma. Researchers want t…

This study is testing a new cell therapy for children and young adults (up to age 30) whose leukemia or lymphoma has returned or not responded to other treatments. Doctors take a patient's own immune cells (T-cells), modify them in a lab to recognize a protein called CD22 on canc…

This study is testing whether combining two immunotherapy drugs (nivolumab and ipilimumab) with a chemotherapy drug (azacitidine) is safe and effective for treating myelodysplastic syndromes (MDS), a type of blood and bone marrow cancer. It is for 99 patients, including those new…

This early-stage study is testing if the drug Talazoparib can help control two types of blood cancer (AML and MDS) in patients whose cancers have a specific genetic change called a cohesin mutation. The drug works by blocking a protein that helps cancer cells repair themselves, w…

This study is testing whether adding the drug ponatinib to a specific chemotherapy regimen and another drug called venetoclax can help patients whose T-cell acute lymphoblastic leukemia has returned or not responded to prior treatment. It aims to see if this combination can put t…

This study is testing whether adding a newer targeted drug called ibrutinib to a standard chemotherapy combination (FCR) is safe and more effective for younger patients with CLL who have not yet received any treatment. The main goal is to see if this combination can lead to a dee…

This study is testing if a new pill form of the cancer drug cladribine works similarly to the standard version given through an IV. It involves 40 adults with specific types of leukemia. The main goal is to find the right pill dose that delivers the same amount of drug into the b…

This study is testing an experimental drug called BGB-11417 in adults whose chronic lymphocytic leukemia or small lymphocytic lymphoma has returned or stopped responding to standard treatments. The trial aims to see how well the drug controls the cancer and how safe it is for pat…

This study is testing whether a specific probiotic (Lactobacillus plantarum) can prevent a serious complication called acute graft-versus-host disease (GvHD) in children, teens, and young adults getting a stem cell transplant from a donor for cancers like leukemia or lymphoma. Ab…

This study aimed to see if regular clinic visits and a pneumonia vaccine could help prevent infections in cancer patients after they received CAR-T cell therapy. The plan was to enroll 50 adults with blood cancers or solid tumors who were getting this specialized treatment. Resea…

This study aims to see if adding methadone to standard morphine pain medication better controls severe mouth pain in children aged 6-18 undergoing stem cell transplants. Researchers will compare pain levels, medication use, and recovery between children receiving the two-drug com…

This study is testing whether a specially adapted fencing exercise program is practical and helpful for adults with leukemia or lymphoma who are receiving intensive treatment in the hospital. Researchers want to see if this unique form of physical activity can help patients maint…

This study is testing whether a daily mindfulness meditation app is a practical and helpful way for adult survivors of childhood leukemia or lymphoma to manage stress. Fifty participants will use the Headspace app for 30 days, wear a wrist device to measure stress signals, and an…

This study aims to understand the genetic causes of cancer that run in families. Researchers are collecting blood or saliva samples from patients with certain cancers and their relatives to build a DNA bank. The goal is to identify genetic patterns that increase cancer risk, whic…

This study is testing a new system designed to give doctors a more complete picture of an older patient's overall health and life circumstances when planning cancer treatment. It combines questions about aging, daily function, mental health, and social needs like housing and food…

This study is testing whether a special exercise program is safe and practical for older adults with blood cancers before they receive CAR-T cell therapy. Researchers want to see if patients can stick with the program and if it helps improve their strength and fitness. The goal i…

This study created a large registry to collect information about children with cancer across the United States and Canada. Researchers ask parents to share details about their child's diagnosis and family background to build a comprehensive database. The goal is to help scientist…

This study aims to understand whether exposure to farm environments during childhood increases the risk of developing cancer and other diseases in adulthood. Researchers are following over 64,000 adults who grew up on farms, collecting health information and biological samples ov…

This study aims to collect tissue and blood samples from people who have received or donated bone marrow transplants for blood cancers like leukemia and lymphoma. Researchers will analyze these samples to better understand why complications happen and how to improve transplant su…