LEUKEMIA

This study tests whether a chemotherapy plan used for children with acute lymphoblastic leukemia (ALL) is safe and works well for adults aged 18 to 60 with a certain type of ALL (Philadelphia chromosome-negative). The goal is to see if this approach can control the disease and ac…

This study tests the drug CPI-613 in people with aggressive lymphomas (Burkitt lymphoma or high-grade B-cell lymphoma) that have returned or not responded to prior treatment. The goal is to see if the drug can shrink or control the cancer. The trial involves 24 participants aged …

This study looks at whether giving palifermin and leuprolide acetate can speed up immune recovery in people who have had a stem cell transplant for blood cancers like leukemia or lymphoma. The transplant uses donor stem cells to replace the patient's blood system. The goal is to …

This study tests a new way to prepare patients with leukemia or myelodysplastic syndromes for a donor stem cell transplant. It combines a precise type of radiation (helical tomotherapy) with two chemotherapy drugs (fludarabine and melphalan) to kill cancer cells and prevent rejec…

This study tests a new treatment for children and young adults up to age 30 whose leukemia or lymphoma has come back or not responded to standard therapy. The treatment uses the patient's own immune cells (T cells) that are modified in a lab to recognize and attack cancer cells c…

This study tests a daily pill called PCI-32765 for people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who are over 65 or have a specific genetic change (17p deletion). These groups often don't respond well to standard chemotherapy. The goal is to s…

This early-stage trial tests a new approach for adults with B-cell acute lymphoblastic leukemia (B-ALL) that has returned or not responded to standard treatment. Doctors take a patient's own T cells (a type of immune cell), add a gene that helps them recognize and attack leukemia…

This study tests the safety of the drug neratinib in children and teens with solid tumors, brain tumors, lymphoma, or leukemia that have returned or not responded to standard treatments. The goal is to find the right dose and see what side effects occur. 14 participants are enrol…

This early-phase study tests whether the drug talazoparib can help people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) who have a specific mutation in the cohesin complex. The trial includes 13 participants who cannot receive standard intensive chemotherapy…

This study tests a treatment where a patient's own T cells are genetically modified in a lab to recognize and attack cancer cells that carry a protein called CD19. The approach is for people with relapsed or chemotherapy-resistant chronic lymphocytic leukemia or indolent B-cell l…

This study tests whether adding the targeted drug ibrutinib to standard chemotherapy (FCR) can help younger, untreated patients with chronic lymphocytic leukemia (CLL) achieve a very deep remission, where no cancer cells can be found in the bone marrow. About 85 participants will…

This early-phase study tests a personalized cell therapy for children and young adults with a type of leukemia that has come back or not responded to standard treatments. The therapy uses the patient's own immune cells, modified to recognize two markers (CD19 and CD22) on leukemi…

This study tests whether combining lenalidomide and rituximab can help control chronic lymphocytic leukemia or small lymphocytic lymphoma. It includes 120 adults who either have not been treated before or whose cancer has returned. The goal is to see how well the drugs shrink or …

This study tests a new treatment for people with certain blood cancers (lymphoma, multiple myeloma, or CLL) that have returned or not responded to standard therapy. Researchers take a patient's own immune cells (T cells) and modify them in the lab to better recognize and attack c…

This study looks at whether using stem cells from a younger, more distant relative leads to better survival than using cells from an older immediate family member for people with leukemia or MDS. About 232 participants will be randomly assigned to receive a transplant from either…

This study tests whether the drug ruxolitinib can help people with chronic myelomonocytic leukemia (CMML), a rare blood cancer. About 29 adults will receive the drug to see if it improves blood counts, shrinks the cancer, or keeps it stable. The goal is to control the disease and…

This study is for people with blood cancers like leukemia or lymphoma who have had a stem cell transplant or cell therapy. It tests a new COVID-19 vaccine (GEO-CM04S1) to see if it provides better protection against COVID-19 than the standard mRNA vaccines. The goal is to help th…

This study tests a stem cell transplant from unrelated or partially matched donors for people with blood cancers like leukemia, lymphoma, or myelodysplasia. The donated cells are specially treated to remove certain immune cells, which may help the transplant take hold and reduce …

This study tests an experimental drug called BGB-11417 in 100 adults whose chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) has come back or stopped responding to other treatments. The goal is to see if the drug can shrink or eliminate cancer cells. Particip…

This study tests two drugs, vemurafenib (a pill) and obinutuzumab (an infusion), in 30 people with untreated hairy cell leukemia. The goal is to see if the combination can achieve a complete response, meaning no signs of cancer after treatment. Participants take vemurafenib for 4…

This study tests whether combining two immunotherapy drugs (nivolumab and ipilimumab) with a chemotherapy drug (azacitidine) can help people with myelodysplastic syndromes (MDS), a bone marrow disorder. About 99 adults with MDS, including those who have not responded to prior tre…

This study was designed to test the safety of a new drug called MT-0169 in people with acute leukemia that has come back or not responded to treatment. It was planned for patients aged 12 and older with specific leukemia types. However, the trial was withdrawn before any particip…

This study tests an experimental drug called AZD6738 in adults with myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) whose disease got worse after standard frontline therapy. The main goal is to check the drug's safety and find the right dose. About 52 par…

This study tests whether a probiotic called Lactobacillus plantarum can prevent acute graft-versus-host disease (GvHD) in the gut of children receiving donor stem cell transplants. About 173 children with blood cancers or other conditions will take the probiotic or a placebo. The…

This study looks at whether a special fencing program can help adults with leukemia or lymphoma avoid getting weak during intensive hospital treatment. About 80 patients will try adapted fencing exercises that can be done in bed, a chair, or standing up. The main goal is to see i…

This study looks at whether adding methadone to the usual pain medicine (morphine) can better control severe mouth pain in children aged 6 to 18 who are getting a stem cell transplant for conditions like leukemia or aplastic anemia. The mouth pain, called mucositis, is a common s…

This study collects blood and saliva samples from people with cancer and their family members to build a DNA bank. Researchers will use these samples to study how genes may increase the risk of developing certain cancers. The goal is to better understand inherited cancer tendenci…

This study follows children and teens who have had cancer or a stem cell transplant to see how they do over many years. Researchers collect health information to understand long-term side effects of treatment. The goal is to find ways to reduce problems and improve quality of lif…

This study was designed to track how the immune system recovers after CAR-T cell therapy and whether a pneumonia vaccine (PCV-21) given six months later can work. It planned to enroll 50 adults with blood cancers or solid tumors. However, the study was withdrawn before any partic…

This study creates a large registry to collect information from nearly 58,000 children diagnosed with cancer or similar conditions in the U.S. and Canada. The goal is to help researchers study patterns, causes, and characteristics of childhood cancers. Parents provide details abo…

This study collects white blood cells from people aged 3 to 65 with leukemia or lymphoma that hasn't been cured by standard treatments. The cells are used to create a personalized therapy called CAR T-cells, which may be given later. The procedure, called leukapheresis, takes 4-6…

This study looks at whether a daily mindfulness app can help adult survivors of childhood leukemia or lymphoma manage stress. About 50 participants will use the app for 30 days and wear a wrist device to track stress signs like heart rate and skin temperature. The goal is to see …

This study collects tissue samples from people receiving bone marrow transplants and their donors. Researchers will analyze these samples to identify genes and proteins that may play a role in cancer development and progression. The goal is to better understand transplant outcome…

This study tests a new system that helps doctors better understand the needs of older adults with cancer. The system combines checks on aging, mental health, lifestyle, and social factors. About 35 patients aged 65 and older will try it during their first cancer visit. The goal i…

This study follows about 64,000 adults who grew up on farms to see if early exposure to pesticides and other farm-related factors is linked to cancer. Participants fill out a questionnaire and may provide blood or other samples. The goal is to understand how childhood agricultura…