New combo therapy aims to improve stem cell transplants for leukemia patients
NCT ID NCT00544466
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new conditioning regimen using a precise type of radiation (helical tomotherapy) along with two chemotherapy drugs (fludarabine and melphalan) before a donor stem cell transplant. The goal is to reduce side effects and improve outcomes for people with leukemia or myelodysplastic syndromes. The trial enrolled 75 participants and is no longer recruiting.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- fludarabine phosphate, melphalan, and radiation therapy
- What this could lead to
- If successful, this approach could make stem cell transplants safer and more effective for people with blood cancers.
- What could go wrong
- This is an early-phase trial with only 75 participants, so results may not apply broadly. There are risks of serious side effects from the chemotherapy and radiation.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
City of Hope Medical Center
Duarte, California, 91010-3000, United States
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