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Could methadone ease agonizing mouth pain in kids after transplant?

NCT ID NCT06940570

Terminated Symptom relief Sponsor: University of Texas Southwestern Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding methadone to usual morphine-based pain medicine reduces severe mouth pain in children aged 6–18 who are getting a stem cell transplant for leukemia, aplastic anemia, or similar conditions. The mouth pain is a common side effect of the chemotherapy given before transplant. Researchers hope the combination will lower pain scores and reduce the total amount of opioids needed. The trial is small (60 participants) and currently on hold.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
methadone
What this could lead to
If it works, this could point toward a better way to manage severe mouth pain in children during stem cell transplant recovery.
What could go wrong
The trial is small (60 participants) and currently suspended, so results may not be conclusive. Methadone also has side effects like drowsiness and breathing problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

aplastic anemia Bone Marrow Failure Disorders bone marrow failure syndrome leukemia mucositis neoplasm Pain, Intractable severe combined immunodeficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

APLASTIC ANEMIA BONE MARROW FAILURE SYNDROMES LEUKEMIA SCID

Contacts and locations

Locations

  • Children's Health of Dallas

    Dallas, Texas, 75235, United States

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