Could methadone ease agonizing mouth pain in kids after transplant?
NCT ID NCT06940570
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adding methadone to usual morphine-based pain medicine reduces severe mouth pain in children aged 6–18 who are getting a stem cell transplant for leukemia, aplastic anemia, or similar conditions. The mouth pain is a common side effect of the chemotherapy given before transplant. Researchers hope the combination will lower pain scores and reduce the total amount of opioids needed. The trial is small (60 participants) and currently on hold.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
methadone
What this could lead to
If it works, this could point toward a better way to manage severe mouth pain in children during stem cell transplant recovery.
What could go wrong
The trial is small (60 participants) and currently suspended, so results may not be conclusive. Methadone also has side effects like drowsiness and breathing problems.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Children's Health of Dallas
Dallas, Texas, 75235, United States