New hope for kids with tough cancers: neratinib trial underway
NCT ID NCT02932280
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests the safety and effectiveness of neratinib, a targeted cancer drug, in children whose solid tumors, brain tumors, lymphoma, or leukemia have come back or not responded to standard treatments. The drug is taken by mouth daily in 28-day cycles. The main goal is to find the best dose and see how the drug affects the cancer and the child.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Neratinib (a targeted cancer drug taken by mouth)
What this could lead to
If it works, this could offer a new treatment option for children with hard-to-treat cancers that have not responded to standard therapy.
What could go wrong
This is an early-phase trial with only 14 participants, so results may not apply broadly. The drug may cause side effects like diarrhea or low blood counts, and it may not shrink tumors.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Alberta Children'S Hospital
Calgary, Alberta, T3B 6A8, Canada
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Arkansas Children's Hospital
Little Rock, Arkansas, 72206, United States
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Arnold Palmer Hospital for Children
Orlando, Florida, 32806, United States
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Huntsman Cancer Institue
Salt Lake City, Utah, 84113, United States
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Memorial Sloan Kettering Cancer Center
New York, New York, 10065, United States
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Pennsylvania State Hershey Children's Hospital
Hershey, Pennsylvania, 17033, United States
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Phoenix Children'S Hospital
Phoenix, Arizona, 85016, United States
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Stanford University School of Medicine and Stanford Cancer Institute
Palo Alto, California, 94304, United States
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University of Texas
San Antonio, Texas, 78229, United States