New hope for kids with tough cancers: neratinib trial underway

NCT ID NCT02932280

Ongoing Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests the safety and effectiveness of neratinib, a targeted cancer drug, in children whose solid tumors, brain tumors, lymphoma, or leukemia have come back or not responded to standard treatments. The drug is taken by mouth daily in 28-day cycles. The main goal is to find the best dose and see how the drug affects the cancer and the child.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Neratinib (a targeted cancer drug taken by mouth)
What this could lead to: If it works, this could offer a new treatment option for children with hard-to-treat cancers that have not responded to standard therapy.
What could go wrong: This is an early-phase trial with only 14 participants, so results may not apply broadly. The drug may cause side effects like diarrhea or low blood counts, and it may not shrink tumors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

central nervous system cancer disease leukemia lymphoma neoplasm Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CENTRAL NERVOUS SYSTEM TUMOR LEUKEMIA LYMPHOMA SOLID TUMOR

Contacts and locations

Locations

Alberta Children'S Hospital

Calgary, Alberta, T3B 6A8, Canada
Arkansas Children's Hospital

Little Rock, Arkansas, 72206, United States
Arnold Palmer Hospital for Children

Orlando, Florida, 32806, United States
Huntsman Cancer Institue

Salt Lake City, Utah, 84113, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Pennsylvania State Hershey Children's Hospital

Hershey, Pennsylvania, 17033, United States
Phoenix Children'S Hospital

Phoenix, Arizona, 85016, United States
Stanford University School of Medicine and Stanford Cancer Institute

Palo Alto, California, 94304, United States
University of Texas

San Antonio, Texas, 78229, United States

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